TY - JOUR
T1 - Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function
AU - Goldowitz, Dan
AU - Frankel, Wayne N.
AU - Takahashi, Joseph S.
AU - Holtz-Vitaterna, Martha
AU - Bult, Carol
AU - Kibbe, Warren A.
AU - Snoddy, Jay
AU - Li, Yanxia
AU - Pretel, Stephanie
AU - Yates, Jeana
AU - Swanson, Douglas J.
N1 - Funding Information:
We would like to thank all the members of each Mutagenesis Center for their contributions to this community effort. This work is generously supported by cooperative agreements U01-MH61971 (TMGC), U01-MH61915 (NU), U01-NS41215 (TJL).
PY - 2004/12/20
Y1 - 2004/12/20
N2 - N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium (http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.
AB - N-ethyl-N-nitrosourea (ENU) mutagenesis is presented as a powerful approach to developing models for human disease. The efforts of three NIH Mutagenesis Centers established for the detection of neuroscience-related phenotypes are described. Each center has developed an extensive panel of phenotype screens that assess nervous system structure and function. In particular, these screens focus on complex behavioral traits from drug and alcohol responses to circadian rhythms to epilepsy. Each of these centers has developed a bioinformatics infrastructure to track the extensive number of transactions that are inherent in these large-scale projects. Over 100 new mouse mutant lines have been defined through the efforts of these three mutagenesis centers and are presented to the research community via the centralized Web presence of the Neuromice.org consortium (http://www.neuromice.org). This community resource provides visitors with the ability to search for specific mutant phenotypes, to view the genetic and phenotypic details of mutant mouse lines, and to order these mice for use in their own research program.
KW - Functional genomics
KW - Mouse mutants behavioral phenotype
KW - N-ethyl-N-nitrosourea (ENU)
KW - Neurogenetics
UR - http://www.scopus.com/inward/record.url?scp=9944236320&partnerID=8YFLogxK
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U2 - 10.1016/j.molbrainres.2004.09.016
DO - 10.1016/j.molbrainres.2004.09.016
M3 - Article
C2 - 15582151
AN - SCOPUS:9944236320
SN - 0169-328X
VL - 132
SP - 105
EP - 115
JO - Molecular Brain Research
JF - Molecular Brain Research
IS - 2
ER -