Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

J. C. Goodman; S. P. Gopinath; A. B. Valadka; R. K. Narayan; R. G. Grossman; R. K. Simpson; C. S. Robertson

doi:10.1007/978-3-7091-6894-3_8

Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

J. C. Goodman, S. P. Gopinath, A. B. Valadka, R. K. Narayan, R. G. Grossman, R. K. Simpson, C. S. Robertson

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.

Original language	English (US)
Pages (from-to)	37-39
Number of pages	3
Journal	Acta Neurochirurgica, Supplement
Volume	1996
Issue number	67
DOIs	https://doi.org/10.1007/978-3-7091-6894-3_8
State	Published - 1996
Externally published	Yes

Keywords

Amino acids
Glutamate aspartate: Excitotoxicity
Head injury
Ischemia
Microdialysis: Lactic acid

ASJC Scopus subject areas

Surgery
Clinical Neurology

Access to Document

10.1007/978-3-7091-6894-3_8

Cite this

@article{3074ad1e546b455082ffa5757ef659fb,

title = "Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury",

abstract = "We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.",

keywords = "Amino acids, Glutamate aspartate: Excitotoxicity, Head injury, Ischemia, Microdialysis: Lactic acid",

author = "Goodman, {J. C.} and Gopinath, {S. P.} and Valadka, {A. B.} and Narayan, {R. K.} and Grossman, {R. G.} and Simpson, {R. K.} and Robertson, {C. S.}",

year = "1996",

doi = "10.1007/978-3-7091-6894-3_8",

language = "English (US)",

volume = "1996",

pages = "37--39",

journal = "Acta Neurochirurgica, Supplement",

issn = "0065-1419",

publisher = "Springer Wien",

number = "67",

}

TY - JOUR

T1 - Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

AU - Goodman, J. C.

AU - Gopinath, S. P.

AU - Valadka, A. B.

AU - Narayan, R. K.

AU - Grossman, R. G.

AU - Simpson, R. K.

AU - Robertson, C. S.

PY - 1996

Y1 - 1996

N2 - We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.

AB - We examined the extracellular neurochemical milieu in 34 head injured patients using microdialysis while simultaneously monitoring intracranial pressure, cerebral perfusion pressure, and jugular venous oxygen saturation. Derangements of anaerobic metabolism reflected by increased lactate and lactate/pyruvate ratios, and release of amino acids were seen at the same time as physiological deterioration in the majority of instances. Clinical microdialysis may provide insights into the neurochemistry of head injury, and such information may lead to new methods of monitoring and treating head injured patients.

KW - Amino acids

KW - Glutamate aspartate: Excitotoxicity

KW - Head injury

KW - Ischemia

KW - Microdialysis: Lactic acid

UR - http://www.scopus.com/inward/record.url?scp=0030332801&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030332801&partnerID=8YFLogxK

U2 - 10.1007/978-3-7091-6894-3_8

DO - 10.1007/978-3-7091-6894-3_8

M3 - Article

C2 - 8870799

AN - SCOPUS:0030332801

SN - 0065-1419

VL - 1996

SP - 37

EP - 39

JO - Acta Neurochirurgica, Supplement

JF - Acta Neurochirurgica, Supplement

IS - 67

ER -

Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this