@article{299d2a37e4b94c5fab84e3a674e31b77,
title = "Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress",
abstract = "Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.",
keywords = "ERK, LDHA, NDRG3, cardiac hypertrophy, heart failure, lactate, pathological cardiac remodeling, pressure overload",
author = "Chongshan Dai and Qinfeng Li and May, {Herman I.} and Chao Li and Guangyu Zhang and Gaurav Sharma and Sherry, {A. Dean} and Malloy, {Craig R.} and Chalermchai Khemtong and Yuannyu Zhang and Yingfeng Deng and Gillette, {Thomas G.} and Jian Xu and Scadden, {David T.} and Wang, {Zhao V.}",
note = "Funding Information: We thank John Shelton and the Molecular Pathology Core of University of Texas Southwestern Medical Center (UTSW) for help with histology. We are grateful to the Animal Resource Center of UTSW for mouse generation, breeding, and maintenance. This work was supported by grants from the American Heart Association (18POST34050049 to G.S.; 14SDG18440002, 17IRG33460191, and 19IPLOI34760325 to Z.V.W.) and NIH (R37-HL034557 to A.D.S.; P41-EB015908 to C.R.M.; R01-DK111430 and R01-CA230631 to J.X.; R01-HL137723 to Z.V.W.). C.D. and Z.V.W. conceived and designed the study. C.D. performed most experiments with help from Q.L. H.I.M. and G.Z. (animal surgery); G.S. A.D.S. C.R.M. and C.K. (metabolic analysis); and Y.Z. and J.X. (RNA-seq analysis). C.D. and Z.V.W. wrote the manuscript with the help of C.L. Y.D. T.G.G. and D.T.S. All authors revised and approved the manuscript. The authors declare no competing interests. Funding Information: We thank John Shelton and the Molecular Pathology Core of University of Texas Southwestern Medical Center (UTSW) for help with histology. We are grateful to the Animal Resource Center of UTSW for mouse generation, breeding, and maintenance. This work was supported by grants from the American Heart Association ( 18POST34050049 to G.S.; 14SDG18440002 , 17IRG33460191 , and 19IPLOI34760325 to Z.V.W.) and NIH ( R37-HL034557 to A.D.S.; P41-EB015908 to C.R.M.; R01-DK111430 and R01-CA230631 to J.X.; R01-HL137723 to Z.V.W.). Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = sep,
day = "1",
doi = "10.1016/j.celrep.2020.108087",
language = "English (US)",
volume = "32",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "9",
}