Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Chongshan Dai; Qinfeng Li; Herman I. May; Chao Li; Guangyu Zhang; Gaurav Sharma; A. Dean Sherry; Craig R. Malloy; Chalermchai Khemtong; Yuannyu Zhang; Yingfeng Deng; Thomas G. Gillette; Jian Xu; David T. Scadden; Zhao V. Wang

doi:10.1016/j.celrep.2020.108087

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Chongshan Dai, Qinfeng Li, Herman I. May, Chao Li, Guangyu Zhang, Gaurav Sharma, A. Dean Sherry, Craig R. Malloy, Chalermchai Khemtong, Yuannyu Zhang, Yingfeng Deng, Thomas G. Gillette, Jian Xu, David T. Scadden, Zhao V. Wang

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.

Original language	English (US)
Article number	108087
Journal	Cell Reports
Volume	32
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2020.108087
State	Published - Sep 1 2020

Keywords

ERK
LDHA
NDRG3
cardiac hypertrophy
heart failure
lactate
pathological cardiac remodeling
pressure overload

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2020.108087

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title = "Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress",

abstract = "Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.",

keywords = "ERK, LDHA, NDRG3, cardiac hypertrophy, heart failure, lactate, pathological cardiac remodeling, pressure overload",

author = "Chongshan Dai and Qinfeng Li and May, {Herman I.} and Chao Li and Guangyu Zhang and Gaurav Sharma and Sherry, {A. Dean} and Malloy, {Craig R.} and Chalermchai Khemtong and Yuannyu Zhang and Yingfeng Deng and Gillette, {Thomas G.} and Jian Xu and Scadden, {David T.} and Wang, {Zhao V.}",

note = "Publisher Copyright: {\textcopyright} 2020 The Author(s)",

year = "2020",

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doi = "10.1016/j.celrep.2020.108087",

language = "English (US)",

volume = "32",

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TY - JOUR

T1 - Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

AU - Dai, Chongshan

AU - Li, Qinfeng

AU - May, Herman I.

AU - Li, Chao

AU - Zhang, Guangyu

AU - Sharma, Gaurav

AU - Sherry, A. Dean

AU - Malloy, Craig R.

AU - Khemtong, Chalermchai

AU - Zhang, Yuannyu

AU - Deng, Yingfeng

AU - Gillette, Thomas G.

AU - Xu, Jian

AU - Scadden, David T.

AU - Wang, Zhao V.

PY - 2020/9/1

Y1 - 2020/9/1

N2 - Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.

AB - Dai et al. find that LDHA is significantly increased in the heart under hemodynamic stress, and cardiomyocyte-specific deletion of LDHA leads to severe cardiac dysfunction in response to pressure overload. LDHA may govern adaptive growth through elevation of NDRG3 and activation of ERK.

KW - ERK

KW - LDHA

KW - NDRG3

KW - cardiac hypertrophy

KW - heart failure

KW - lactate

KW - pathological cardiac remodeling

KW - pressure overload

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DO - 10.1016/j.celrep.2020.108087

M3 - Article

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SN - 2211-1247

VL - 32

JO - Cell Reports

JF - Cell Reports

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ER -

Lactate Dehydrogenase A Governs Cardiac Hypertrophic Growth in Response to Hemodynamic Stress

Abstract

Keywords

ASJC Scopus subject areas

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