Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome

Kazuma Ohyashiki; Jerry W. Shay; Junko H. Ohyashiki

Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome

Kazuma Ohyashiki, Jerry W. Shay, Junko H. Ohyashiki

Research output: Contribution to journal › Article › peer-review

Abstract

Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit telomere attrition.

Original language	English (US)
Pages (from-to)	691
Number of pages	1
Journal	Haematologica
Volume	90
Issue number	5
State	Published - May 2005

Keywords

HTERC mutations
Myelodysplastic syndrome
Telomerase

ASJC Scopus subject areas

Hematology

Cite this

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abstract = "Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit telomere attrition.",

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AB - Myelodysplastic syndrome (MDS), considered a pre-leukemic state, has recently been categorized as a subset of bone marrow failure syndromes. Unlike other subtypes of bone marrow failure syndromes, such as aplastic anemia or dyskeratosis congenita, little is known about genetic alterations of human telomerase in MDS, despite the fact that immune cells from patients with MDS frequently exhibit telomere attrition.

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Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome

Abstract

Keywords

ASJC Scopus subject areas

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