TY - JOUR
T1 - L1, a novel target of β-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers
AU - Gavert, Nancy
AU - Conacci-Sorrell, Maralice
AU - Gast, Daniela
AU - Schneider, Annette
AU - Altevogt, Peter
AU - Brabletz, Thomas
AU - Ben-Ze'Ev, Avri
PY - 2005/2/14
Y1 - 2005/2/14
N2 - A berrant β-catenin-TCF target gene activation plays a key role in colorectal cancer, both in the initiation stage and during invasion and metastasis. We identified the neuronal cell adhesion molecule L1, as a target gene of β-catenin-TCF signaling in colorectal cancer cells. L1 expression was high in sparse cultures and coregulated with ADAM10, a metalloprotease involved in cleaving and shedding L1's extracellular domain. L1 expression conferred increased cell motility, growth in low serum, transformation and tumorigenesis, whereas its suppression in colon cancer cells decreased motility. L1 was exclusively localized in the invasive front of human colorectal tumors together with ADAM10. The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy.
AB - A berrant β-catenin-TCF target gene activation plays a key role in colorectal cancer, both in the initiation stage and during invasion and metastasis. We identified the neuronal cell adhesion molecule L1, as a target gene of β-catenin-TCF signaling in colorectal cancer cells. L1 expression was high in sparse cultures and coregulated with ADAM10, a metalloprotease involved in cleaving and shedding L1's extracellular domain. L1 expression conferred increased cell motility, growth in low serum, transformation and tumorigenesis, whereas its suppression in colon cancer cells decreased motility. L1 was exclusively localized in the invasive front of human colorectal tumors together with ADAM10. The transmembrane localization and shedding of L1 by metalloproteases could be useful for detection and as target for colon cancer therapy.
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U2 - 10.1083/jcb.200408051
DO - 10.1083/jcb.200408051
M3 - Article
C2 - 15716380
AN - SCOPUS:13944268218
SN - 0021-9525
VL - 168
SP - 633
EP - 642
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 4
ER -