Knowledge-based potential functions in protein design

William P. Russ, Rama Ranganathan

Research output: Contribution to journalReview articlepeer-review

64 Scopus citations


Predicting protein sequences that fold into specific native three-dimensional structures is a problem of great potential complexity. Although the complete solution is ultimately rooted in understanding the physical chemistry underlying the complex interactions between amino acid residues that determine protein stability, recent work shows that empirical information about these first principles is embedded in the statistics of protein sequence and structure databases. This review focuses on the use of 'knowledge-based' potentials derived from these databases in designing proteins. In addition, the data suggest how the study of these empirical potentials might impact our fundamental understanding of the energetic principles of protein structure.

Original languageEnglish (US)
Pages (from-to)447-452
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number4
StatePublished - Aug 1 2002

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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