Klotho and the aging process

Makoto Kuro-o

Research output: Contribution to journalReview articlepeer-review

109 Scopus citations


The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.

Original languageEnglish (US)
Pages (from-to)113-122
Number of pages10
JournalKorean Journal of Internal Medicine
Issue number2
StatePublished - Jun 2011


  • Fibroblast growth factor
  • Klotho
  • Phosphate
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine


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