Ketogenesis in vitro

J. D. McGarry; D. W. Foster

doi:10.1016/0304-4165(69)90061-0

Ketogenesis in vitro

J. D. McGarry, D. W. Foster

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Starvation for 48 h and diabetes (induced either by alloxan treatment or by pancreatectomy) resulted in increasing degrees of ketosis in rats. Optimal conditions were established for acetoacetate synthesis from CoASAc in homogenates of liver taken from animals of all experimental groups. The results obtained from these studies show that the dramatic increase in ketosis associated with starvation and diabetes cannot be accounted for by the minor fluctuations observed in the levels of hepatic enzymes responsible for ketogenesis.

Original language	English (US)
Pages (from-to)	35-41
Number of pages	7
Journal	BBA - General Subjects
Volume	177
Issue number	1
DOIs	https://doi.org/10.1016/0304-4165(69)90061-0
State	Published - Feb 18 1969

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

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title = "Ketogenesis in vitro",

abstract = "Starvation for 48 h and diabetes (induced either by alloxan treatment or by pancreatectomy) resulted in increasing degrees of ketosis in rats. Optimal conditions were established for acetoacetate synthesis from CoASAc in homogenates of liver taken from animals of all experimental groups. The results obtained from these studies show that the dramatic increase in ketosis associated with starvation and diabetes cannot be accounted for by the minor fluctuations observed in the levels of hepatic enzymes responsible for ketogenesis.",

author = "McGarry, {J. D.} and Foster, {D. W.}",

note = "Funding Information: This study was supported by grant CA 08269, U.S. Public Health Service. J.O.M. is supported by a grant from the Damon Runyon Cancer Fund. D.W.F. is a Research Career Development Awardee (5-Ks-AM 9968), U.S. Public Health Service. The authors wish to thank Miss JOANNE GUEST for expert technical assistance.",

year = "1969",

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doi = "10.1016/0304-4165(69)90061-0",

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T1 - Ketogenesis in vitro

AU - McGarry, J. D.

AU - Foster, D. W.

N1 - Funding Information: This study was supported by grant CA 08269, U.S. Public Health Service. J.O.M. is supported by a grant from the Damon Runyon Cancer Fund. D.W.F. is a Research Career Development Awardee (5-Ks-AM 9968), U.S. Public Health Service. The authors wish to thank Miss JOANNE GUEST for expert technical assistance.

PY - 1969/2/18

Y1 - 1969/2/18

N2 - Starvation for 48 h and diabetes (induced either by alloxan treatment or by pancreatectomy) resulted in increasing degrees of ketosis in rats. Optimal conditions were established for acetoacetate synthesis from CoASAc in homogenates of liver taken from animals of all experimental groups. The results obtained from these studies show that the dramatic increase in ketosis associated with starvation and diabetes cannot be accounted for by the minor fluctuations observed in the levels of hepatic enzymes responsible for ketogenesis.

AB - Starvation for 48 h and diabetes (induced either by alloxan treatment or by pancreatectomy) resulted in increasing degrees of ketosis in rats. Optimal conditions were established for acetoacetate synthesis from CoASAc in homogenates of liver taken from animals of all experimental groups. The results obtained from these studies show that the dramatic increase in ketosis associated with starvation and diabetes cannot be accounted for by the minor fluctuations observed in the levels of hepatic enzymes responsible for ketogenesis.

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Ketogenesis in vitro

Abstract

ASJC Scopus subject areas

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