TY - JOUR
T1 - Keratin-18
T2 - Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis
AU - McClain, Craig J.
AU - Vatsalya, Vatsalya
AU - Mitchell, Mack C.
N1 - Publisher Copyright:
© 2021 Wolters Kluwer Health. All rights reserved.
PY - 2021/1/1
Y1 - 2021/1/1
N2 - It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.
AB - It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis), predicting 90-day mortality, and predicting the response to corticosteroid therapy in severe AH. The authors conclude that K18 is diagnostic, prognostic, and may be a theragnostic marker for prednisolone therapy and note that "serum K18 estimation should be adopted into routine clinical practice." We agree.
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U2 - 10.14309/ajg.0000000000001042
DO - 10.14309/ajg.0000000000001042
M3 - Review article
C2 - 33306505
AN - SCOPUS:85099322171
SN - 0002-9270
VL - 116
SP - 77
EP - 79
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 1
ER -