Karyopherins and nuclear import

Min Chook Yuh, Günter Blobel

Research output: Contribution to journalReview articlepeer-review

421 Scopus citations


Proteins of the karyopherin α and karyopherin β families play a central role in nucleocytoplasmic transport. Recently, crystal structures of karyopherin α and its complexes with nuclear localization signal peptides, a karyopherin β2-Ran complex and complexes of full-length and fragments of karyopherin β1 with import substrates, Ran and nucleoporins have been solved. These karyopherin structures provide valuable insights into understanding the molecular mechanism of nuclear import, especially substrate recognition, substrate release by GTPase and interactions with the nuclear pore complex.

Original languageEnglish (US)
Pages (from-to)703-715
Number of pages13
JournalCurrent Opinion in Structural Biology
Issue number6
StatePublished - Dec 1 2001

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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