Kallikrein gene expression in estrogen-induced pituitary tumors

Peter J. Fuller; Bronwyn A. Matheson; Raymond J. MacDonald; Karen Verity; Judith A. Clements

doi:10.1016/0303-7207(88)90182-7

Kallikrein gene expression in estrogen-induced pituitary tumors

Peter J. Fuller, Bronwyn A. Matheson, Raymond J. MacDonald, Karen Verity, Judith A. Clements

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Anterior pituitary kallkrein-like enzyme activity, immunoreactivity and mRNA levels have previously been shown to be regulated by estrogen, in parallel with prolactin. In this study, we have examined the relationship between kallikrein and prolactin mRNA levels in estrogen-induced pituitary tumors. Treatment of Fischer 344 rats with diethylstilbestrol implants for 3, 5 and 7 weeks produced a dramatic increase in kallikrein mRNA levels and a modest increase in prolactin mRNA levels. These changes were partially reversed by bromocriptine treatment, and completely reversed by bromocriptine plus estrogen withdrawal. Using a panel of oligonucleotide probes specific for various members of the rat kallikrein gene family, we have shown that the kallikrein-like gene expressed appears to be true kallikrein.

Original language	English (US)
Pages (from-to)	225-232
Number of pages	8
Journal	Molecular and Cellular Endocrinology
Volume	60
Issue number	2-3
DOIs	https://doi.org/10.1016/0303-7207(88)90182-7
State	Published - Dec 1988

Keywords

Anterior pituitary
Bromocriptine
Kallikrein
Prolactin
Prolactinoma

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Endocrinology

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10.1016/0303-7207(88)90182-7

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title = "Kallikrein gene expression in estrogen-induced pituitary tumors",

abstract = "Anterior pituitary kallkrein-like enzyme activity, immunoreactivity and mRNA levels have previously been shown to be regulated by estrogen, in parallel with prolactin. In this study, we have examined the relationship between kallikrein and prolactin mRNA levels in estrogen-induced pituitary tumors. Treatment of Fischer 344 rats with diethylstilbestrol implants for 3, 5 and 7 weeks produced a dramatic increase in kallikrein mRNA levels and a modest increase in prolactin mRNA levels. These changes were partially reversed by bromocriptine treatment, and completely reversed by bromocriptine plus estrogen withdrawal. Using a panel of oligonucleotide probes specific for various members of the rat kallikrein gene family, we have shown that the kallikrein-like gene expressed appears to be true kallikrein.",

keywords = "Anterior pituitary, Bromocriptine, Kallikrein, Prolactin, Prolactinoma",

author = "Fuller, {Peter J.} and Matheson, {Bronwyn A.} and MacDonald, {Raymond J.} and Karen Verity and Clements, {Judith A.}",

note = "Funding Information: This work was supported by the National Health and Medical Research Council of Australia. P.J.F. is a Wellcome Australian Senior Research Fellow in Medical Science. We wish to thank Professor John Shine for the rat PRL cDNA, Dr. William Chin for the rat cY-subunit cDNA, Professor John Funder for his critical reading of the manuscript and Mrs. Sue Smith and Mr. Michael Whitehead for preparation of the manuscript.",

year = "1988",

month = dec,

doi = "10.1016/0303-7207(88)90182-7",

language = "English (US)",

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AU - Fuller, Peter J.

AU - Matheson, Bronwyn A.

AU - MacDonald, Raymond J.

AU - Verity, Karen

AU - Clements, Judith A.

N1 - Funding Information: This work was supported by the National Health and Medical Research Council of Australia. P.J.F. is a Wellcome Australian Senior Research Fellow in Medical Science. We wish to thank Professor John Shine for the rat PRL cDNA, Dr. William Chin for the rat cY-subunit cDNA, Professor John Funder for his critical reading of the manuscript and Mrs. Sue Smith and Mr. Michael Whitehead for preparation of the manuscript.

PY - 1988/12

Y1 - 1988/12

N2 - Anterior pituitary kallkrein-like enzyme activity, immunoreactivity and mRNA levels have previously been shown to be regulated by estrogen, in parallel with prolactin. In this study, we have examined the relationship between kallikrein and prolactin mRNA levels in estrogen-induced pituitary tumors. Treatment of Fischer 344 rats with diethylstilbestrol implants for 3, 5 and 7 weeks produced a dramatic increase in kallikrein mRNA levels and a modest increase in prolactin mRNA levels. These changes were partially reversed by bromocriptine treatment, and completely reversed by bromocriptine plus estrogen withdrawal. Using a panel of oligonucleotide probes specific for various members of the rat kallikrein gene family, we have shown that the kallikrein-like gene expressed appears to be true kallikrein.

AB - Anterior pituitary kallkrein-like enzyme activity, immunoreactivity and mRNA levels have previously been shown to be regulated by estrogen, in parallel with prolactin. In this study, we have examined the relationship between kallikrein and prolactin mRNA levels in estrogen-induced pituitary tumors. Treatment of Fischer 344 rats with diethylstilbestrol implants for 3, 5 and 7 weeks produced a dramatic increase in kallikrein mRNA levels and a modest increase in prolactin mRNA levels. These changes were partially reversed by bromocriptine treatment, and completely reversed by bromocriptine plus estrogen withdrawal. Using a panel of oligonucleotide probes specific for various members of the rat kallikrein gene family, we have shown that the kallikrein-like gene expressed appears to be true kallikrein.

KW - Anterior pituitary

KW - Bromocriptine

KW - Kallikrein

KW - Prolactin

KW - Prolactinoma

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JO - Molecular and Cellular Endocrinology

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ER -

Kallikrein gene expression in estrogen-induced pituitary tumors

Abstract

Keywords

ASJC Scopus subject areas

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