@article{64539bc07cc84a1086035c0f713f8c41,
title = "JmjC domain proteins modulate circadian behaviors and sleep in Drosophila",
abstract = "Jumonji (JmjC) domain proteins are known regulators of gene expression and chromatin organization by way of histone demethylation. Chromatin modification and remodeling provides a means to modulate the activity of large numbers of genes, but the importance of this class of predicted histone-modifying enzymes for different aspects of post-developmental processes remains poorly understood. Here we test the function of all 11 non-lethal members in the regulation of circadian rhythms and sleep. We find loss of every Drosophila JmjC gene affects different aspects of circadian behavior and sleep in a specific manner. Together these findings suggest that the majority of JmjC proteins function as regulators of behavior, rather than controlling essential developmental programs.",
author = "Shalaby, {Nevine A.} and Pinzon, {Jorge H.} and Narayanan, {Anjana S.} and Jin, {Eugene Jennifer} and Ritz, {Morgan P.} and Dove, {Rachel J.} and Heike Wolfenberg and Rodan, {Aylin R.} and Michael Buszczak and Adrian Rothenfluh",
note = "Funding Information: N.A.S. was supported by the American Heart Association and NIH (Training grant DK 7745–17). This work was supported in various phases by NIAAA (R01AA019526 to A.R., R21AA022404 to A.R. & M.B.), NIDDK (K08DK091316 and R01DK110358 to ARR), The March of Dimes (#5FY09–10), NIHGMS (1R01GM086647) and Cancer Prevention Research Institute of Texas (RP100516) to M.B. We would like to thank the Bloomington Drosophila Stock Center and the Developmental Studies Hybridoma Bank for reagents, Robin Hiesinger, Helmut Kramer, Lauren Tyra, Zeynep Okray, Bassem Hassan and members of the Buszczak and Rothenfluh labs for comments and advice. The authors declare no competing financial interests. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-017-18989-1",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}