Ivabradine toxicity: a case report

Kavisha Singh; Muthukumar R. Alagarraju; Carl E. Wolf; Justin L. Poklis; Nitin K Kulkarni; William Tharpe; Parag H. Joshi

doi:10.1186/s13256-022-03554-w

Ivabradine toxicity: a case report

Kavisha Singh, Muthukumar R. Alagarraju, Carl E. Wolf, Justin L. Poklis, Nitin K Kulkarni, William Tharpe, Parag H. Joshi

Research output: Contribution to journal › Article › peer-review

Abstract

Background: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. Case presentation: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. Conclusions: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity.

Original language	English (US)
Article number	392
Journal	Journal of Medical Case Reports
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s13256-022-03554-w
State	Published - Dec 2022

Keywords

Arrhythmias
Cardiology
Case report
Pharmacokinetics

ASJC Scopus subject areas

General Medicine

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10.1186/s13256-022-03554-w

Cite this

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title = "Ivabradine toxicity: a case report",

abstract = "Background: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. Case presentation: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. Conclusions: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity.",

keywords = "Arrhythmias, Cardiology, Case report, Pharmacokinetics",

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AU - Singh, Kavisha

AU - Alagarraju, Muthukumar R.

AU - Wolf, Carl E.

AU - Poklis, Justin L.

AU - Kulkarni, Nitin K

AU - Tharpe, William

AU - Joshi, Parag H.

PY - 2022/12

Y1 - 2022/12

N2 - Background: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. Case presentation: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. Conclusions: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity.

AB - Background: We describe a case of symptomatic bradycardia resulting from ivabradine toxicity by measurement of ivabradine levels, of which there are limited reports in the literature. Case presentation: A 43-year-old White female presented with several days of near syncope and dizziness accompanied by a drop in her heart rate to 50 beats per minute. She was taking ivabradine for inappropriate sinus tachycardia. After excluding several other causes of bradycardia, we made the diagnosis of ivabradine toxicity by measurement of serum ivabradine levels, an approach that is currently not clinically available. Conclusions: Measurement of serum ivabradine levels and knowledge of the pharmacokinetic properties of the drug can be utilized to confirm the diagnosis of ivabradine toxicity.

KW - Arrhythmias

KW - Cardiology

KW - Case report

KW - Pharmacokinetics

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Ivabradine toxicity: a case report

Abstract

Keywords

ASJC Scopus subject areas

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