Ivabradine Overdose in a Newborn: Precautions of Dispensing in Infants

Pezad Doctor; William A. Scott; Kaitlin Tindel; Hoang H. Nguyen

doi:10.14740/cr1392

Ivabradine Overdose in a Newborn: Precautions of Dispensing in Infants

Pezad Doctor, William A. Scott, Kaitlin Tindel, Hoang H. Nguyen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Ivabradine is currently approved to reduce heart rate in children with chronic heart failure and dilated cardiomyopathy. Ivabradine has also been used off-label in children to treat automatic tachyarrhythmias such as ectopic atrial tachycardia and junctional ectopic tachycardia. Adverse effects of ivabradine at physiological doses as well as its toxicity at supra-physiological doses have rarely been reported in adults. In children, weight-based dosing requires dilution of commercially available ivabradine oral solution for accuracy. We describe a case of ivabradine overdose in a newborn (treated for ectopic atrial tachycardia) secondary to inaccurate dosing leading to the infant receiving 10 times more drug than prescribed.

Original language	English (US)
Pages (from-to)	242-245
Number of pages	4
Journal	Cardiology Research
Volume	13
Issue number	4
DOIs	https://doi.org/10.14740/cr1392
State	Published - Aug 2022

Keywords

Ectopic atrial tachycardia
Ivabradine toxicity
Newborn
Sinus bradycardia

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.14740/cr1392

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abstract = "Ivabradine is currently approved to reduce heart rate in children with chronic heart failure and dilated cardiomyopathy. Ivabradine has also been used off-label in children to treat automatic tachyarrhythmias such as ectopic atrial tachycardia and junctional ectopic tachycardia. Adverse effects of ivabradine at physiological doses as well as its toxicity at supra-physiological doses have rarely been reported in adults. In children, weight-based dosing requires dilution of commercially available ivabradine oral solution for accuracy. We describe a case of ivabradine overdose in a newborn (treated for ectopic atrial tachycardia) secondary to inaccurate dosing leading to the infant receiving 10 times more drug than prescribed.",

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AU - Doctor, Pezad

AU - Scott, William A.

AU - Tindel, Kaitlin

AU - Nguyen, Hoang H.

N1 - Publisher Copyright: © The authors | Journal compilation

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AB - Ivabradine is currently approved to reduce heart rate in children with chronic heart failure and dilated cardiomyopathy. Ivabradine has also been used off-label in children to treat automatic tachyarrhythmias such as ectopic atrial tachycardia and junctional ectopic tachycardia. Adverse effects of ivabradine at physiological doses as well as its toxicity at supra-physiological doses have rarely been reported in adults. In children, weight-based dosing requires dilution of commercially available ivabradine oral solution for accuracy. We describe a case of ivabradine overdose in a newborn (treated for ectopic atrial tachycardia) secondary to inaccurate dosing leading to the infant receiving 10 times more drug than prescribed.

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Ivabradine Overdose in a Newborn: Precautions of Dispensing in Infants

Abstract

Keywords

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