Abstract
We have isolated and sequenced the mouse preprodynorphin gene (Pdyn). The Pdyn gene can encode for six biologically active dynorphin peptides. The predicted mouse preprodynorphin has 90%, 67%, and 66% identity with the predicted rat, porcine, and human preprodynorphins, respectively. Using an RT-PCR technique, we show that the Pdyn gene starts being expressed at embryonic day 12.5, with a steep increase of expression by embryonic day 14.5; in the adult mouse it is expressed in the brain, but not in liver, heart, spleen, or kidney.
Original language | English (US) |
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Pages (from-to) | 236-238 |
Number of pages | 3 |
Journal | Neuropeptides |
Volume | 33 |
Issue number | 3 |
DOIs | |
State | Published - Jun 1999 |
ASJC Scopus subject areas
- Endocrinology
- Neurology
- Endocrine and Autonomic Systems
- Cellular and Molecular Neuroscience