Isolated symptomatic peripheral neuropathy in type 1 insulin-dependent diabetes mellitus

Luis Ramirez, Julio Rosenstock, Susan Mullen, Michael Koffler, Ralph Greenlee, George Sanborn, Philip Raskin

Research output: Contribution to journalArticlepeer-review


Diabetic neuropathy is probably the most frequent of the chronic complications of diabetes, and is usually found in association with diabetic retinopathy and/or nephropathy. We report seven patients with long-standing insulin-dependent diabetes mellitus in whom symptomatic peripheral neuropathy was the first and only documented complication. The diagnosis of peripheral symmetrical neuropathy was based on the presence of symptoms and abnormal physical findings, confirmed with abnormal electrophysiological and/or vibratory and thermal threshold measurements. Diabetic retinopathy and nephropathy were absent. We conclude that in some type 1 insulin-dependent diabetic patients, similar to what has been reported in type 2 non-insulin-dependent diabetes, peripheral neuropathy may be the first chronic complication to become manifest. This observation provides additional evidence to suggest that each of the diabetic complications may have a different pathogenic mechanism.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalDiabetes Research and Clinical Practice
Issue number3
StatePublished - 1989


  • Insulin-dependent diabetes mellitus
  • Neuropathy, diabetic
  • Neuropathy, peripheral

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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