TY - JOUR
T1 - Isolated symptomatic peripheral neuropathy in type 1 insulin-dependent diabetes mellitus
AU - Ramirez, Luis
AU - Rosenstock, Julio
AU - Mullen, Susan
AU - Koffler, Michael
AU - Greenlee, Ralph
AU - Sanborn, George
AU - Raskin, Philip
PY - 1989
Y1 - 1989
N2 - Diabetic neuropathy is probably the most frequent of the chronic complications of diabetes, and is usually found in association with diabetic retinopathy and/or nephropathy. We report seven patients with long-standing insulin-dependent diabetes mellitus in whom symptomatic peripheral neuropathy was the first and only documented complication. The diagnosis of peripheral symmetrical neuropathy was based on the presence of symptoms and abnormal physical findings, confirmed with abnormal electrophysiological and/or vibratory and thermal threshold measurements. Diabetic retinopathy and nephropathy were absent. We conclude that in some type 1 insulin-dependent diabetic patients, similar to what has been reported in type 2 non-insulin-dependent diabetes, peripheral neuropathy may be the first chronic complication to become manifest. This observation provides additional evidence to suggest that each of the diabetic complications may have a different pathogenic mechanism.
AB - Diabetic neuropathy is probably the most frequent of the chronic complications of diabetes, and is usually found in association with diabetic retinopathy and/or nephropathy. We report seven patients with long-standing insulin-dependent diabetes mellitus in whom symptomatic peripheral neuropathy was the first and only documented complication. The diagnosis of peripheral symmetrical neuropathy was based on the presence of symptoms and abnormal physical findings, confirmed with abnormal electrophysiological and/or vibratory and thermal threshold measurements. Diabetic retinopathy and nephropathy were absent. We conclude that in some type 1 insulin-dependent diabetic patients, similar to what has been reported in type 2 non-insulin-dependent diabetes, peripheral neuropathy may be the first chronic complication to become manifest. This observation provides additional evidence to suggest that each of the diabetic complications may have a different pathogenic mechanism.
KW - Insulin-dependent diabetes mellitus
KW - Neuropathy, diabetic
KW - Neuropathy, peripheral
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U2 - 10.1016/0168-8227(89)90009-0
DO - 10.1016/0168-8227(89)90009-0
M3 - Article
C2 - 2558008
AN - SCOPUS:0024424196
SN - 0168-8227
VL - 7
SP - 227
EP - 233
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
IS - 3
ER -