Isolated Mitral Cleft in Trisomy 21: An Initially ‘Silent’ Lesion

Poonam P. Thankavel, Claudio Ramaciotti

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Congenital cardiac anomalies are common in trisomy 21, and transthoracic echocardiogram within the first month of life is recommended. While a cleft mitral valve associated with atrioventricular septal defect has been well defined in this population, the prevalence of isolated mitral valve cleft has not been previously reported. The aim of our study was to define the occurrence of isolated mitral cleft in the first echocardiogram of patients with trisomy 21. This retrospective chart review examined echocardiographic data on all Trisomy 21 patients

Original languageEnglish (US)
Pages (from-to)405-408
Number of pages4
JournalPediatric Cardiology
Issue number2
StatePublished - Feb 1 2016


  • Cleft
  • Down syndrome
  • Isolated mitral cleft
  • Trisomy 21

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health


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