@article{a99f6c96f38d43a883383cb553c38537,
title = "Is there a future for AKT inhibitors in the treatment of cancer?",
abstract = "An AKT inhibitor plus an antiestrogen exhibited no significant clinical activity in patients with ER+/HER2- breast cancer despite laboratory studies supporting an antitumor effect for both drugs combined. These results raise concerns about the development of AKT inhibitors in unselected patients whose tumors have unknown dependence on the PI3K/AKT pathway.",
author = "Jansen, {Valerie M.} and Mayer, {Ingrid A.} and Arteaga, {Carlos L.}",
note = "Funding Information: This work was supported by the NIH under the Breast Cancer Specialized Program of Research Excellence (SPORE) grant P50CA98131 (to C.L. Arteaga) and Vanderbilt-Ingram Cancer Center Support grant P30CA68485 (to C.L. Arteaga). Publisher Copyright: {\textcopyright} 2016 American Association for Cancer Research.",
year = "2016",
month = jun,
day = "1",
doi = "10.1158/1078-0432.CCR-16-0100",
language = "English (US)",
volume = "22",
pages = "2599--2601",
journal = "Clinical Cancer Research",
issn = "1078-0432",
publisher = "American Association for Cancer Research Inc.",
number = "11",
}