Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?

Martin Sénéchal, Colby R. Ayers, Lidia S. Szczepaniak, M. Odette Gore, Raphael See, Shuaib M Abdullah, Jarett D Berry, Darren K McGuire, Jonathan M. McGavock

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). Materials and methods: Patients (n = 74) with T2DM and ≥ 1 additional cardiac risk factor were recruited to participate in this cross-sectional study. Outcome measures of interest were LV structure and function by magnetic resonance imaging (MRI) and myocardial TG content by 1H-magnetic resonance spectroscopy (MRS). The primary exposure variable was cardiorespiratory fitness defined by peak oxygen consumption scaled to fat-free mass (FFM; VO 2peak-FFM). Results: Mean age was 53.5 years; 42.9% were women and mean glycosylated haemoglobin (HbA1c) was 8.0% with the mean duration of T2DM 8.2 years. VO2peak-FFM was crudely associated with both LV end systolic (r = 0.35, p = 0.002) and diastolic volumes (r = 0.32, p = 0.004), but not with ejection fraction (r = -0.15, p = 0.206), myocardial TG (r = -0.04, p = 0.734) or early diastolic peak filling rate (PFR; r = -0.01, p = 0.887). In multiple linear regression analyses, among measures of LV structure/function, VO2peak-FFM was independently associated only with LV end-diastolic volume (EDV) (β = 1.037, p = 0.038). Conclusion: In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalDiabetes and Vascular Disease Research
Issue number5
StatePublished - Sep 2014


  • Obesity
  • diabetes mellitus
  • ectopic fat
  • exercise

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine


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