TY - JOUR
T1 - Is cardiorespiratory fitness a determinant of cardiomyopathy in the setting of type 2 diabetes?
AU - Sénéchal, Martin
AU - Ayers, Colby R.
AU - Szczepaniak, Lidia S.
AU - Gore, M. Odette
AU - See, Raphael
AU - Abdullah, Shuaib M
AU - Berry, Jarett D
AU - McGuire, Darren K
AU - McGavock, Jonathan M.
N1 - Funding Information:
We would like to thank the Manitoba Health Research Council, The Canadian Institute of Health Research and the Integrated and Mentored Pulmonary and Cardiovascular Training that supports the salary and the training of Dr Sénéchal. Dr McGavock is supported by a New Investigator Salary Award from the Canadian Institutes of Health Research. Dr McGuire has received research support from Daiichi Sankyo, Eli Lilly, Merck, Bristol-Myers Squibb, Boehringer Ingelheim, Genentech, F. Hoffmann-La Roche, Eisai, Omthera, Takeda, GlaxoSmithKline and Novo Nordisk and is a consultant for Janssen Pharmaceuticals, Boehringer Ingelheim, Regeneron, Genentech, Merck, Sanofi-Aventis and Takeda.
PY - 2014/9
Y1 - 2014/9
N2 - Objective: The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). Materials and methods: Patients (n = 74) with T2DM and ≥ 1 additional cardiac risk factor were recruited to participate in this cross-sectional study. Outcome measures of interest were LV structure and function by magnetic resonance imaging (MRI) and myocardial TG content by 1H-magnetic resonance spectroscopy (MRS). The primary exposure variable was cardiorespiratory fitness defined by peak oxygen consumption scaled to fat-free mass (FFM; VO 2peak-FFM). Results: Mean age was 53.5 years; 42.9% were women and mean glycosylated haemoglobin (HbA1c) was 8.0% with the mean duration of T2DM 8.2 years. VO2peak-FFM was crudely associated with both LV end systolic (r = 0.35, p = 0.002) and diastolic volumes (r = 0.32, p = 0.004), but not with ejection fraction (r = -0.15, p = 0.206), myocardial TG (r = -0.04, p = 0.734) or early diastolic peak filling rate (PFR; r = -0.01, p = 0.887). In multiple linear regression analyses, among measures of LV structure/function, VO2peak-FFM was independently associated only with LV end-diastolic volume (EDV) (β = 1.037, p = 0.038). Conclusion: In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content.
AB - Objective: The aim of this study was to determine whether high fitness attenuates the defects in left ventricular (LV) structure, function and triglyceride (TG) content in patients with type 2 diabetes mellitus (T2DM). Materials and methods: Patients (n = 74) with T2DM and ≥ 1 additional cardiac risk factor were recruited to participate in this cross-sectional study. Outcome measures of interest were LV structure and function by magnetic resonance imaging (MRI) and myocardial TG content by 1H-magnetic resonance spectroscopy (MRS). The primary exposure variable was cardiorespiratory fitness defined by peak oxygen consumption scaled to fat-free mass (FFM; VO 2peak-FFM). Results: Mean age was 53.5 years; 42.9% were women and mean glycosylated haemoglobin (HbA1c) was 8.0% with the mean duration of T2DM 8.2 years. VO2peak-FFM was crudely associated with both LV end systolic (r = 0.35, p = 0.002) and diastolic volumes (r = 0.32, p = 0.004), but not with ejection fraction (r = -0.15, p = 0.206), myocardial TG (r = -0.04, p = 0.734) or early diastolic peak filling rate (PFR; r = -0.01, p = 0.887). In multiple linear regression analyses, among measures of LV structure/function, VO2peak-FFM was independently associated only with LV end-diastolic volume (EDV) (β = 1.037, p = 0.038). Conclusion: In individuals with T2DM at increased cardiovascular (CV) risk, cardiorespiratory fitness is not associated with LV morphology, function or myocardial TG content.
KW - Obesity
KW - diabetes mellitus
KW - ectopic fat
KW - exercise
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U2 - 10.1177/1479164114540924
DO - 10.1177/1479164114540924
M3 - Article
C2 - 25027700
AN - SCOPUS:84906053970
SN - 1479-1641
VL - 11
SP - 343
EP - 351
JO - Diabetes and Vascular Disease Research
JF - Diabetes and Vascular Disease Research
IS - 5
ER -