TY - JOUR
T1 - Involvement of Brd4 in different steps of the papillomavirus life cycle
AU - Iftner, Thomas
AU - Haedicke-Jarboui, Juliane
AU - Wu, Shwu Yuan
AU - Chiang, Cheng Ming
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2017/3/2
Y1 - 2017/3/2
N2 - Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4’s activity in order to create a facilitating environment for the viral life cycle. Brd4, in association with the major viral regulatory protein E2, is involved in multiple steps of the PV life cycle including replication initiation, viral gene transcription, and viral genome segregation and maintenance. Phosphorylation of Brd4, regulated by casein kinase II (CK2) and protein phosphatase 2A (PP2A), is critical for viral gene transcription as well as E1- and E2-dependent origin replication. Thus, pharmacological agents regulating Brd4 phosphorylation and inhibitors blocking phospho-Brd4 functions are promising candidates for therapeutic intervention in treating human papillomavirus (HPV) infections as well as associated disease.
AB - Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4’s activity in order to create a facilitating environment for the viral life cycle. Brd4, in association with the major viral regulatory protein E2, is involved in multiple steps of the PV life cycle including replication initiation, viral gene transcription, and viral genome segregation and maintenance. Phosphorylation of Brd4, regulated by casein kinase II (CK2) and protein phosphatase 2A (PP2A), is critical for viral gene transcription as well as E1- and E2-dependent origin replication. Thus, pharmacological agents regulating Brd4 phosphorylation and inhibitors blocking phospho-Brd4 functions are promising candidates for therapeutic intervention in treating human papillomavirus (HPV) infections as well as associated disease.
KW - Brd4
KW - E2 protein
KW - Papillomavirus life cycle
KW - Papillomavirus replication
KW - Papillomavirus transcription
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U2 - 10.1016/j.virusres.2016.12.006
DO - 10.1016/j.virusres.2016.12.006
M3 - Review article
C2 - 27965149
AN - SCOPUS:85007564016
SN - 0168-1702
VL - 231
SP - 76
EP - 82
JO - Virus Research
JF - Virus Research
ER -