Investigation of cerebral hemodynamic changes during a repeated sit-stand maneuver using functional near-infrared spectroscopy

Haijing Niu, Lin Li, Gauri S. Bhave, Zi Jing Lin, Fenghua Tian, Behbehani Khosrow, Rong Zhang, Hanli Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations


The goal for this study is to examine cerebral autoregulation in response to a repeated sit-stand maneuver using both diffuse functional Near Infrared spectroscopy (fNIRS) and Transcranial Doppler sonography (TCD). While fNIRS can provide transient changes in hemodynamic response to such a physical action, TCD is a noninvasive transcranial method to detect the flow velocities in the basal or middle cerebral arteries (MCA). The initial phase of this study was to measure fNIRS signals from the forehead of subjects during the repeated sit-stand protocol and to understand the corresponding meaning of the detected signals. Also, we acquired preliminary data from simultaneous measurements of fNIRS and TCD during the sit-stand protocol so as to explore the technical difficulty of such an approach. Specifically, ten healthy adult subjects were enrolled to perform the planned protocol, and the fNIRS array probes with 4 sources and 10 detectors were placed on the subject's forehead to detect hemodynamic signal changes from the prefrontal cortex. The fNIRS results show that the oscillations of hemoglobin concentration were spatially global and temporally dynamic across the entire region of subject's forehead. The oscillation patterns in both hemoglobin concentrations and blood flow velocity seemed to follow one another; changes in oxy-hemoglobin concentration were much larger than those in deoxy-hemoglobin concentration. These preliminary findings provide us with evidence that fNIRS is an appropriate means readily for studying cerebral hemodynamics and autoregulation during sit-stand maneuvers.

Original languageEnglish (US)
Title of host publicationDynamics and Fluctuations in Biomedical Photonics VIII
StatePublished - 2011
EventDynamics and Fluctuations in Biomedical Photonics VIII - San Francisco, CA, United States
Duration: Jan 22 2011Jan 24 2011

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherDynamics and Fluctuations in Biomedical Photonics VIII
Country/TerritoryUnited States
CitySan Francisco, CA


  • Cerebral autoregulation
  • Cerebral metabolic rate of oxygen
  • Near infrared spectroscopy
  • Sit-stand maneuver
  • TCD

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging
  • Biomaterials


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