TY - JOUR
T1 - Investigation into Possible Association of Oxandrolone and Heterotopic Ossification Following Burn Injury
AU - Thorpe, Catherine R.
AU - Ucer Ozgurel, Serra
AU - Simko, Laura C.
AU - Goldstein, Richard
AU - Grant, Gabrielle G.
AU - Pagani, Chase
AU - Hwang, Charles
AU - Vasquez, Kaetlin
AU - Sorkin, Michael
AU - Vaishampayan, Anita
AU - Goverman, Jeremy
AU - Sheridan, Robert L.
AU - Friedstat, Jonathan
AU - Schulz, John T.
AU - Schneider, Jeffrey C.
AU - Levi, Benjamin
AU - Ryan, Colleen M.
N1 - Funding Information:
From the *Massachusetts General Hospital, Boston; †Shriners Hospitals for Children-Boston, Massachusetts; ‡University of Michigan, Ann Arbor; ||Spaulding Rehabilitation Hospital, Charlestown, Massachusetts; $Harvard Medical School, Cambridge, Massachusetts Funding: B.L. is funded by the National Institutes of Health R01GM123069, the National Institute of General Medical Sciences K08GM109105, and the American College of Surgeons Clowes Award. M.S. is funded by the Plastic Surgery Foundation National Endowment Award and C.H. is funded by the Howard Hughes Medical Institute Medical Student Scholar Award. C.T. was supported by the Shriners Hospitals for Children Helen Lemieux Scholarship. J.S., L.S., R.G. and C.R. were supported in part by National Institute on Disability, Independent Living and Rehabilitation Research (NIDILRR #90DPBU0001), G.G. and C.R. were supported in part by Shriners Hospitals for Children, Grant #72000 and the Fraser Fund of the Massachusetts General Hospital.
Publisher Copyright:
© American Burn Association 2019. All rights reserved.
PY - 2019/6/21
Y1 - 2019/6/21
N2 - Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed with logistic regression. Associations of oxandrolone with HO were examined in a mouse model. Mice were administered oxandrolone or vehicle control following burn/tenotomy to examine any potential effect of oxandrolone on HO and were analyzed by Student's t test. Subjects who received oxandrolone had a higher incidence of elbow HO than those that did not receive oxandrolone. However, when controlling for oxandrolone administration, oxandrolone duration, postburn day oxandrolone initiation, HO risk score category, age, sex, race, burn size, and year of injury, there was no significant difference between rates of elbow HO between the two populations. In agreement with the review, in the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance.
AB - Oxandrolone, a testosterone analog, is used to counteract the catabolic effects of burn injury. Recent animal studies suggest a possible hormonal association with heterotopic ossification (HO) development postburn. This work examines oxandrolone administration and HO development by exploring historical clinical data bridging the introduction of oxandrolone into clinical practice. Additionally, we examine associations between oxandrolone administration and HO in a standardized mouse model of burn/trauma-related HO. Acutely burned adults admitted between 2000 and 2014, survived through discharge, and had a HO risk factor of 7 or higher were selected for analysis from a single burn center. Oxandrolone administration, clinical and demographic data, and elbow HO were recorded and were analyzed with logistic regression. Associations of oxandrolone with HO were examined in a mouse model. Mice were administered oxandrolone or vehicle control following burn/tenotomy to examine any potential effect of oxandrolone on HO and were analyzed by Student's t test. Subjects who received oxandrolone had a higher incidence of elbow HO than those that did not receive oxandrolone. However, when controlling for oxandrolone administration, oxandrolone duration, postburn day oxandrolone initiation, HO risk score category, age, sex, race, burn size, and year of injury, there was no significant difference between rates of elbow HO between the two populations. In agreement with the review, in the mouse model, while there was a trend toward the oxandrolone group developing a greater volume of HO, this did not reach statistical significance.
UR - http://www.scopus.com/inward/record.url?scp=85068537959&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068537959&partnerID=8YFLogxK
U2 - 10.1093/jbcr/irz063
DO - 10.1093/jbcr/irz063
M3 - Article
C2 - 31053861
AN - SCOPUS:85068537959
SN - 1559-047X
VL - 40
SP - 398
EP - 405
JO - Journal of Burn Care and Research
JF - Journal of Burn Care and Research
IS - 4
M1 - irz063
ER -