TY - JOUR
T1 - Intrinsic plasticity
T2 - An emerging player in addiction
AU - Kourrich, Saïd
AU - Calu, Donna J.
AU - Bonci, Antonello
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/2/20
Y1 - 2015/2/20
N2 - Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain circuits, and a prevailing view is that these changes play a part in drug addiction. Notably, there has been intense focus on drug-induced changes in synaptic excitability and much less attention on intrinsic excitability factors (that is, excitability factors that are remote from the synapse). Accumulating evidence now suggests that intrinsic factors such as K + channels are not only altered by cocaine but may also contribute to the shaping of the addiction phenotype.
AB - Exposure to drugs of abuse, such as cocaine, leads to plastic changes in the activity of brain circuits, and a prevailing view is that these changes play a part in drug addiction. Notably, there has been intense focus on drug-induced changes in synaptic excitability and much less attention on intrinsic excitability factors (that is, excitability factors that are remote from the synapse). Accumulating evidence now suggests that intrinsic factors such as K + channels are not only altered by cocaine but may also contribute to the shaping of the addiction phenotype.
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U2 - 10.1038/nrn3877
DO - 10.1038/nrn3877
M3 - Review article
C2 - 25697160
AN - SCOPUS:84923604259
SN - 1471-003X
VL - 16
SP - 173
EP - 184
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
IS - 3
ER -