Intrinsic Functional Connectivity of Dentate Nuclei in Autism Spectrum Disorder

Sheeba Arnold Anteraper, Xavier Guell, Hoyt Patrick Taylor, Anila D'Mello, Susan Whitfield-Gabrieli, Gagan Joshi

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Cerebellar abnormalities are commonly reported in autism spectrum disorder (ASD). Dentate nuclei (DNs) are key structures in the anatomical circuits linking the cerebellum to the extracerebellum. Previous resting-state functional connectivity (RsFc) analyses reported DN abnormalities in high-functioning ASD (HF-ASD). This study examined the RsFc of the DN in young adults with HF-ASD compared with healthy controls (HCs) with the aim to expand upon previous findings of DNs in a dataset using advanced, imaging acquisition methods that optimize spatiotemporal resolution and statistical power. Additional seed-to-voxel analyses were carried out using motor and nonmotor DN coordinates reported in previous studies as seeds. We report abnormal dentato-cerebral and dentato-cerebellar functional connectivity in ASD. Our results expand and, in part, replicate previous descriptions of DN RsFc abnormalities in this disorder and reveal correlations between DN-cerebral RsFc and ASD symptom severity.

Original languageEnglish (US)
Pages (from-to)692-702
Number of pages11
JournalBrain Connectivity
Issue number9
StatePublished - Nov 2019
Externally publishedYes


  • autism spectrum disorder
  • cerebellum
  • dentate nucleus
  • functional connectivity
  • resting state networks
  • social cognition

ASJC Scopus subject areas

  • Neuroscience(all)


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