Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Amy C. Young; Larissa I. Velez; Kurt C. Kleinschmidt

doi:10.1016/j.resuscitation.2009.01.023

Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Amy C. Young, Larissa I. Velez, Kurt C. Kleinschmidt

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

Original language	English (US)
Pages (from-to)	591-593
Number of pages	3
Journal	Resuscitation
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.resuscitation.2009.01.023
State	Published - May 2009

Keywords

Calcium channel blockers
Intralipid fat emulsion
Lipids
Lipophilic
Resuscitation
Verapamil

ASJC Scopus subject areas

Emergency Medicine
Emergency
Cardiology and Cardiovascular Medicine

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10.1016/j.resuscitation.2009.01.023

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abstract = "We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.",

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AB - We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

KW - Calcium channel blockers

KW - Intralipid fat emulsion

KW - Lipids

KW - Lipophilic

KW - Resuscitation

KW - Verapamil

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Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Abstract

Keywords

ASJC Scopus subject areas

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