Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Amy C. Young; Larissa I. Velez; Kurt C. Kleinschmidt

doi:10.1016/j.resuscitation.2009.01.023

Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Amy C. Young, Larissa I. Velez, Kurt C. Kleinschmidt

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

Original language	English (US)
Pages (from-to)	591-593
Number of pages	3
Journal	Resuscitation
Volume	80
Issue number	5
DOIs	https://doi.org/10.1016/j.resuscitation.2009.01.023
State	Published - May 1 2009

Keywords

Calcium channel blockers
Intralipid fat emulsion
Lipids
Lipophilic
Resuscitation
Verapamil

ASJC Scopus subject areas

Emergency Medicine
Emergency
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.resuscitation.2009.01.023

Cite this

@article{b5b230793dab4680868e671c17af1cfd,

title = "Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose",

abstract = "We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.",

keywords = "Calcium channel blockers, Intralipid fat emulsion, Lipids, Lipophilic, Resuscitation, Verapamil",

author = "Young, {Amy C.} and Velez, {Larissa I.} and Kleinschmidt, {Kurt C.}",

year = "2009",

month = may,

day = "1",

doi = "10.1016/j.resuscitation.2009.01.023",

language = "English (US)",

volume = "80",

pages = "591--593",

journal = "Resuscitation",

issn = "0300-9572",

publisher = "Elsevier Ireland Ltd",

number = "5",

}

TY - JOUR

T1 - Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

AU - Young, Amy C.

AU - Velez, Larissa I.

AU - Kleinschmidt, Kurt C.

PY - 2009/5/1

Y1 - 2009/5/1

N2 - We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

AB - We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.

KW - Calcium channel blockers

KW - Intralipid fat emulsion

KW - Lipids

KW - Lipophilic

KW - Resuscitation

KW - Verapamil

UR - http://www.scopus.com/inward/record.url?scp=65249151387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65249151387&partnerID=8YFLogxK

U2 - 10.1016/j.resuscitation.2009.01.023

DO - 10.1016/j.resuscitation.2009.01.023

M3 - Article

C2 - 19282085

AN - SCOPUS:65249151387

SN - 0300-9572

VL - 80

SP - 591

EP - 593

JO - Resuscitation

JF - Resuscitation

IS - 5

ER -

Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this