TY - JOUR
T1 - Intraductal Carcinoma of the Pancreas
AU - Milchgrub, S.
AU - Campuzano, M.
AU - Casillas, J.
AU - Albores-Saavedra, J.
PY - 1992/2/1
Y1 - 1992/2/1
N2 - Four multicentric intraductal papillary carcinomas arising in the main pancreatic duct are presented. Three of the neoplasms showed stromal invasion and metastasized to regional lymph nodes. Three patients had a long history of epigastric pain, confirming the progressive slow growth and less aggressive nature of this clinico‐pathologic entity. Histologically, all tumors were papillary, and three also showed a pseudocribriform pattern. Individual cells exhibited a range of atypia from mild to overt malignant change. Focal intestinal‐differentiation was recognized in two tumors. Despite the well‐differentiated appearance of these tumors, two patients died within 1 year of surgery. One patient with an entirely intraductal carcinoma is alive and well 3 years after surgical treatment. The fourth patient who had lymph node metastasis is alive 6 months after a Whipple's procedure.
AB - Four multicentric intraductal papillary carcinomas arising in the main pancreatic duct are presented. Three of the neoplasms showed stromal invasion and metastasized to regional lymph nodes. Three patients had a long history of epigastric pain, confirming the progressive slow growth and less aggressive nature of this clinico‐pathologic entity. Histologically, all tumors were papillary, and three also showed a pseudocribriform pattern. Individual cells exhibited a range of atypia from mild to overt malignant change. Focal intestinal‐differentiation was recognized in two tumors. Despite the well‐differentiated appearance of these tumors, two patients died within 1 year of surgery. One patient with an entirely intraductal carcinoma is alive and well 3 years after surgical treatment. The fourth patient who had lymph node metastasis is alive 6 months after a Whipple's procedure.
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U2 - 10.1002/1097-0142(19920201)69:3<651::AID-CNCR2820690309>3.0.CO;2-#
DO - 10.1002/1097-0142(19920201)69:3<651::AID-CNCR2820690309>3.0.CO;2-#
M3 - Article
C2 - 1309676
AN - SCOPUS:0026529186
SN - 0008-543X
VL - 69
SP - 651
EP - 656
JO - Cancer
JF - Cancer
IS - 3
ER -