Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Praveena S. Marconescu; Joan E. Smallshaw; Laurentiu M. Pop; Stephen L. Ruback; Ellen S. Vitetta

doi:10.1016/j.vaccine.2010.05.045

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Praveena S. Marconescu, Joan E. Smallshaw, Laurentiu M. Pop, Stephen L. Ruback, Ellen S. Vitetta

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

Original language	English (US)
Pages (from-to)	5315-5322
Number of pages	8
Journal	Vaccine
Volume	28
Issue number	32
DOIs	https://doi.org/10.1016/j.vaccine.2010.05.045
State	Published - Jul 2010

Keywords

Intradermal
Ricin
Vaccine

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2010.05.045

Cite this

@article{90c732b5089246cbb415d7b098ee399c,

title = "Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication",

abstract = "Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.",

keywords = "Intradermal, Ricin, Vaccine",

author = "Marconescu, {Praveena S.} and Smallshaw, {Joan E.} and Pop, {Laurentiu M.} and Ruback, {Stephen L.} and Vitetta, {Ellen S.}",

year = "2010",

month = jul,

doi = "10.1016/j.vaccine.2010.05.045",

language = "English (US)",

volume = "28",

pages = "5315--5322",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "32",

}

TY - JOUR

T1 - Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

AU - Marconescu, Praveena S.

AU - Smallshaw, Joan E.

AU - Pop, Laurentiu M.

AU - Ruback, Stephen L.

AU - Vitetta, Ellen S.

PY - 2010/7

Y1 - 2010/7

N2 - Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

AB - Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

KW - Intradermal

KW - Ricin

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=77954958642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954958642&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2010.05.045

DO - 10.1016/j.vaccine.2010.05.045

M3 - Article

C2 - 20562013

AN - SCOPUS:77954958642

SN - 0264-410X

VL - 28

SP - 5315

EP - 5322

JO - Vaccine

JF - Vaccine

IS - 32

ER -

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this