Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Praveena S. Marconescu; Joan E. Smallshaw; Laurentiu M. Pop; Stephen L. Ruback; Ellen S. Vitetta

doi:10.1016/j.vaccine.2010.05.045

Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Praveena S. Marconescu, Joan E. Smallshaw, Laurentiu M. Pop, Stephen L. Ruback, Ellen S. Vitetta

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

Original language	English (US)
Pages (from-to)	5315-5322
Number of pages	8
Journal	Vaccine
Volume	28
Issue number	32
DOIs	https://doi.org/10.1016/j.vaccine.2010.05.045
State	Published - Jul 2010

Keywords

Intradermal
Ricin
Vaccine

ASJC Scopus subject areas

Molecular Medicine
General Immunology and Microbiology
General Veterinary
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1016/j.vaccine.2010.05.045

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title = "Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication",

abstract = "Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.",

keywords = "Intradermal, Ricin, Vaccine",

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T1 - Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

AU - Marconescu, Praveena S.

AU - Smallshaw, Joan E.

AU - Pop, Laurentiu M.

AU - Ruback, Stephen L.

AU - Vitetta, Ellen S.

PY - 2010/7

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N2 - Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

AB - Ricin toxin is a CDC level B biothreat. We have developed a ricin vaccine, RiVax, which is a recombinant mutant of ricin A chain. RiVax is safe, immunogenic and protective in mice when administered intramuscularly (IM). We have now attempted to increase the utility and immunogenicity of RiVax by administering it intradermally (ID) with or without alum. Without alum, Rivax administered by the ID and IM routes was equally immunogenic and protective. With alum, ID vaccinations were more immunogenic and protective against both systemic and mucosal challenge with ricin and superior in protecting animals from ricin-induced lung damage.

KW - Intradermal

KW - Ricin

KW - Vaccine

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Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication

Abstract

Keywords

ASJC Scopus subject areas

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