Intracerebral Hodgkin's lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: A case report and literature review

Khaldoun Almhanna; Nicholas Wongchaowart; John Sweetenham

doi:10.1080/07357900802189824

Intracerebral Hodgkin's lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: A case report and literature review

Khaldoun Almhanna, Nicholas Wongchaowart, John Sweetenham

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Richter's syndrome is defined as the transformation of low grade lymphoma to more aggressive high grade malignant form, usually diffuse large B cell lymphoma. Primary or metastatic cerebral Hodgkin's lymphoma and Hodgkin's lymphoma variant of Richter transformation are extremely rare. We report a case of 65-year old man who developed isolated intracerebral Hodgkin's lymphoma almost 8 years after the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma, and we reviewed the related literature. The patient had resection of his CNS lesion, followed by radiation and chemotherapy. The patient eventually died with progressive disease.

Original language	English (US)
Pages (from-to)	215-220
Number of pages	6
Journal	Cancer Investigation
Volume	27
Issue number	2
DOIs	https://doi.org/10.1080/07357900802189824
State	Published - Feb 2009
Externally published	Yes

Keywords

Epstein-BarR
Fludarabine
Richter
Transformation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1080/07357900802189824

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abstract = "Richter's syndrome is defined as the transformation of low grade lymphoma to more aggressive high grade malignant form, usually diffuse large B cell lymphoma. Primary or metastatic cerebral Hodgkin's lymphoma and Hodgkin's lymphoma variant of Richter transformation are extremely rare. We report a case of 65-year old man who developed isolated intracerebral Hodgkin's lymphoma almost 8 years after the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma, and we reviewed the related literature. The patient had resection of his CNS lesion, followed by radiation and chemotherapy. The patient eventually died with progressive disease.",

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AB - Richter's syndrome is defined as the transformation of low grade lymphoma to more aggressive high grade malignant form, usually diffuse large B cell lymphoma. Primary or metastatic cerebral Hodgkin's lymphoma and Hodgkin's lymphoma variant of Richter transformation are extremely rare. We report a case of 65-year old man who developed isolated intracerebral Hodgkin's lymphoma almost 8 years after the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma, and we reviewed the related literature. The patient had resection of his CNS lesion, followed by radiation and chemotherapy. The patient eventually died with progressive disease.

KW - Epstein-BarR

KW - Fludarabine

KW - Richter

KW - Transformation

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Intracerebral Hodgkin's lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: A case report and literature review

Abstract

Keywords

ASJC Scopus subject areas

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