Intracellular targeting of protein kinases and phosphatases

Neal Alto, Jennifer J. Carlisle Michel, Kimberly L. Dodge, Lorene K. Langeberg, John D. Scott

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.

Original languageEnglish (US)
Pages (from-to)S385-S388
Issue numberSUPPL. 3
StatePublished - Dec 1 2002

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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