Intracellular targeting of protein kinases and phosphatases

Neal Alto; Jennifer J. Carlisle Michel; Kimberly L. Dodge; Lorene K. Langeberg; John D. Scott

doi:10.2337/diabetes.51.2007.s385

Intracellular targeting of protein kinases and phosphatases

Neal Alto, Jennifer J. Carlisle Michel, Kimberly L. Dodge, Lorene K. Langeberg, John D. Scott

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger-mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). This study focused on recent advances that further our understanding of AKAPs, with particular emphasis on the bidirectional regulation of signaling events by AKAP signaling complexes and their contribution to the control of actin reorganization events.

Original language	English (US)
Pages (from-to)	S385-S388
Journal	Diabetes
Volume	51
Issue number	SUPPL. 3
DOIs	https://doi.org/10.2337/diabetes.51.2007.s385
State	Published - Dec 1 2002

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

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10.2337/diabetes.51.2007.s385

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AU - Carlisle Michel, Jennifer J.

AU - Dodge, Kimberly L.

AU - Langeberg, Lorene K.

AU - Scott, John D.

PY - 2002/12/1

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ER -

Intracellular targeting of protein kinases and phosphatases

Abstract

ASJC Scopus subject areas

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