TY - JOUR
T1 - Intracellular calcium channels
T2 - Inositol-1,4,5-trisphosphate receptors
AU - Fedorenko, Olena A.
AU - Popugaeva, Elena
AU - Enomoto, Masahiro
AU - Stathopulos, Peter B.
AU - Ikura, Mitsuhiko
AU - Bezprozvanny, Ilya
N1 - Funding Information:
IB is a holder of the Carl J. and Hortense M. Thomsen Chair in Alzheimer's Disease Research. MI holds the Canada Research Chair in Cancer Structural Biology. This work was supported by the Dynasty Foundation Grant DP-B-11/13 (EP), Welch Foundation Grant I-1754 (IB), NIH Grants R01NS080152 (IB), R01NS074376 (IB), and R01NS056224 (IB), by the contract with the Russian Ministry of Science 11.G34.31.0056 (IB), by the State Fund for Fundamental Researches in Ukraine DFFD F 46.2/001 (O.F), the Heart and Stroke Foundation of Canada (MI), the Natural Sciences and Engineering Research Council of Canada (MI), and the Canadian Institutes of Health Research (MI).
Publisher Copyright:
© 2013 Elsevier B.V. All rights reserved.
PY - 2014/9/15
Y1 - 2014/9/15
N2 - The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca2+-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca2+ events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is the most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms of InsP3R function and modulation. Cell biological and biochemical studies lead to identification of a large number of InsP3R-binding proteins. InsP3Rs are involved in the regulation of numerous physiological processes, including learning and memory, proliferation, differentiation, development and cell death. Malfunction of InsP3R1 play a role in a number of neurodegenerative disorders and other disease states. InsP3Rs represent a potentially valuable drug target for treatment of these disorders and for modulating activity of neurons and other cells. Future studies will provide better understanding of physiological functions of InsP3Rs in health and disease.
AB - The inositol-1,4,5-trisphosphate receptors (InsP3Rs) are the major intracellular Ca2+-release channels in cells. Activity of InsP3Rs is essential for elementary and global Ca2+ events in the cell. There are three InsP3Rs isoforms that are present in mammalian cells. In this review we will focus primarily on InsP3R type 1. The InsP3R1 is a predominant isoform in neurons and it is the most extensively studied isoform. Combination of biophysical and structural methods revealed key mechanisms of InsP3R function and modulation. Cell biological and biochemical studies lead to identification of a large number of InsP3R-binding proteins. InsP3Rs are involved in the regulation of numerous physiological processes, including learning and memory, proliferation, differentiation, development and cell death. Malfunction of InsP3R1 play a role in a number of neurodegenerative disorders and other disease states. InsP3Rs represent a potentially valuable drug target for treatment of these disorders and for modulating activity of neurons and other cells. Future studies will provide better understanding of physiological functions of InsP3Rs in health and disease.
KW - Ca signaling
KW - Cell nucleus
KW - Inositol 1,4,5-trisphosphate receptors
KW - Neurodegeneration
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U2 - 10.1016/j.ejphar.2013.10.074
DO - 10.1016/j.ejphar.2013.10.074
M3 - Review article
C2 - 24300389
AN - SCOPUS:84924047149
SN - 0014-2999
VL - 739
SP - 39
EP - 48
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
IS - C
ER -