Intestinal stem cell function in Drosophila and mice

Huaqi Jiang, Bruce A. Edgar

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the . Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation.

Original languageEnglish (US)
Pages (from-to)354-360
Number of pages7
JournalCurrent Opinion in Genetics and Development
Issue number4
StatePublished - Aug 2012

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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