Intestinal epithelial Tollerance versus inTollerance of commensals

Elke Cario, Daniel K. Podolsky

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


This brief review summarizes the current understanding of Toll-like receptor (TLRs) mediated intestinal epithelial mechanisms of commensal tolerance versus intolerance and provides an update on the downstream negative control of signaling responses through decreased surface expression, interregulation with NOD2, overexpression of Tollip, various inhibitors of NF-κB as well as soluble tolerizing mediators present in lumen and serum which all may maintain or - when dysregulated - impair mucosal homeostasis in health or disease, respectively.

Original languageEnglish (US)
Pages (from-to)887-893
Number of pages7
JournalMolecular Immunology
Issue number8
StatePublished - May 2005


  • Host-microbe interactions
  • Innate immunity
  • Intestinal epithelium
  • Tolerance
  • Toll-like receptor

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology


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