Interpretation of the mouse electroretinogram

Lawrence H. Pinto; Brandon Invergo; Kazuhiro Shimomura; Joseph S. Takahashi; John B. Troy

doi:10.1007/s10633-007-9064-y

Interpretation of the mouse electroretinogram

Lawrence H. Pinto, Brandon Invergo, Kazuhiro Shimomura, Joseph S. Takahashi, John B. Troy

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The mouse electroretinogram (ERG) consists of a complex set of signals or "waves" generated by multiple types of retinal cell. The origins of these waves are reviewed briefly for the C57BL/6J mouse. The differences in the properties of these waves are described for 34 strains of mice and 11 F1 hybrid mice, as is the way that inter-strain genetic polymorphisms can be exploited in order to help pin-point the genes responsible for ERG differences. There are certain technical difficulties, some subtle, that can arise in recording the ERG and these are classified and illustrated in order to facilitate their diagnosis. Forward genetic screens are described, along with abnormal mice that have been generated in a large screen. Several means are suggested for determining if a mouse having an abnormal ERG is a mutant.

Original language	English (US)
Pages (from-to)	127-136
Number of pages	10
Journal	Documenta Ophthalmologica
Volume	115
Issue number	3
DOIs	https://doi.org/10.1007/s10633-007-9064-y
State	Published - Nov 2007

Keywords

Albino
C57BL/6J
Degeneration
Forward genetics
Genetic transmission
Genotype
Inheritance
Mouse
Retina
Strain variation

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Physiology (medical)

Access to Document

10.1007/s10633-007-9064-y

Cite this

@article{1ee515ea3e79478abeb9d24db846c43d,

title = "Interpretation of the mouse electroretinogram",

abstract = "The mouse electroretinogram (ERG) consists of a complex set of signals or {"}waves{"} generated by multiple types of retinal cell. The origins of these waves are reviewed briefly for the C57BL/6J mouse. The differences in the properties of these waves are described for 34 strains of mice and 11 F1 hybrid mice, as is the way that inter-strain genetic polymorphisms can be exploited in order to help pin-point the genes responsible for ERG differences. There are certain technical difficulties, some subtle, that can arise in recording the ERG and these are classified and illustrated in order to facilitate their diagnosis. Forward genetic screens are described, along with abnormal mice that have been generated in a large screen. Several means are suggested for determining if a mouse having an abnormal ERG is a mutant.",

keywords = "Albino, C57BL/6J, Degeneration, Forward genetics, Genetic transmission, Genotype, Inheritance, Mouse, Retina, Strain variation",

author = "Pinto, {Lawrence H.} and Brandon Invergo and Kazuhiro Shimomura and Takahashi, {Joseph S.} and Troy, {John B.}",

note = "Funding Information: Acknowledgement The faculty and students at the Jackson Laboratory Workshops on Mouse Vision in 2004 and 2006 contributed to the framework for this paper. This work was supported by U01-MH61915 from the NIH.",

year = "2007",

month = nov,

doi = "10.1007/s10633-007-9064-y",

language = "English (US)",

volume = "115",

pages = "127--136",

journal = "Documenta Ophthalmologica",

issn = "0012-4486",

publisher = "Springer Netherlands",

number = "3",

}

TY - JOUR

T1 - Interpretation of the mouse electroretinogram

AU - Pinto, Lawrence H.

AU - Invergo, Brandon

AU - Shimomura, Kazuhiro

AU - Takahashi, Joseph S.

AU - Troy, John B.

N1 - Funding Information: Acknowledgement The faculty and students at the Jackson Laboratory Workshops on Mouse Vision in 2004 and 2006 contributed to the framework for this paper. This work was supported by U01-MH61915 from the NIH.

PY - 2007/11

Y1 - 2007/11

N2 - The mouse electroretinogram (ERG) consists of a complex set of signals or "waves" generated by multiple types of retinal cell. The origins of these waves are reviewed briefly for the C57BL/6J mouse. The differences in the properties of these waves are described for 34 strains of mice and 11 F1 hybrid mice, as is the way that inter-strain genetic polymorphisms can be exploited in order to help pin-point the genes responsible for ERG differences. There are certain technical difficulties, some subtle, that can arise in recording the ERG and these are classified and illustrated in order to facilitate their diagnosis. Forward genetic screens are described, along with abnormal mice that have been generated in a large screen. Several means are suggested for determining if a mouse having an abnormal ERG is a mutant.

AB - The mouse electroretinogram (ERG) consists of a complex set of signals or "waves" generated by multiple types of retinal cell. The origins of these waves are reviewed briefly for the C57BL/6J mouse. The differences in the properties of these waves are described for 34 strains of mice and 11 F1 hybrid mice, as is the way that inter-strain genetic polymorphisms can be exploited in order to help pin-point the genes responsible for ERG differences. There are certain technical difficulties, some subtle, that can arise in recording the ERG and these are classified and illustrated in order to facilitate their diagnosis. Forward genetic screens are described, along with abnormal mice that have been generated in a large screen. Several means are suggested for determining if a mouse having an abnormal ERG is a mutant.

KW - Albino

KW - C57BL/6J

KW - Degeneration

KW - Forward genetics

KW - Genetic transmission

KW - Genotype

KW - Inheritance

KW - Mouse

KW - Retina

KW - Strain variation

UR - http://www.scopus.com/inward/record.url?scp=35748942271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35748942271&partnerID=8YFLogxK

U2 - 10.1007/s10633-007-9064-y

DO - 10.1007/s10633-007-9064-y

M3 - Article

C2 - 17636411

AN - SCOPUS:35748942271

SN - 0012-4486

VL - 115

SP - 127

EP - 136

JO - Documenta Ophthalmologica

JF - Documenta Ophthalmologica

IS - 3

ER -

Interpretation of the mouse electroretinogram

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this