Intermediate endpoint biomarkers for lung cancer chemoprevention

Calum E. MacAulay, Stephen Lam, Helga Klein-Parker, Adi Gazdar, Martial Guillaud, Peter Payne, Jean Le Riche, Chris Dawe, Pierre Band, Branko Palcic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Given the demographics of current and ex-smoking populations in North America, lung cancer will be a major problem in the foreseeable future. Early detection and treatment of lung cancer holds great promise for the management of this disease. Unlike cervical cancer, the physical, complete removal/destruction of all dysplastic lesions in the bronchial tree is not possible; however, treatment of the lesions using a chemopreventive agent is. Intermediate biomarkers have been used to screen promising chemopreventive agents for larger population studies. We have examined the natural history of lung cancer development by following a group of subjects at high risk of developing lung cancer using fluorescence endoscopy to identify the areas of abnormality for biopsy. ∼900 biopsies have been collected in this fashion and graded by at least two experienced, expert pathologists. Using an interactive version of the Cyto-Savant (Oncometrics Imaging Corp.), cytometric and tissue architectural data were collected from these biopsies. Using only the data from the normal and invasive cancer biopsies, quantitative morphometric and architectural indices were generated and calculated for all the collected biopsies. These indices were compared with Loss of Heterozygosity (LOH) of ten sites commonly associated with cancer. These results and the application of these quantitative measures to two small chemoprevention studies will be reported.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsD.L. Farkas, R.C. Leif, B.J. Tromberg
Number of pages5
StatePublished - 1998
EventOptical Investigations of Cells In Vitro and In Vivo - San Jose, CA, United States
Duration: Jan 25 1998Jan 28 1998


OtherOptical Investigations of Cells In Vitro and In Vivo
Country/TerritoryUnited States
CitySan Jose, CA


  • Cellular sociology
  • Chemoprevention
  • LOH
  • Quantitative microscopy

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics


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