Abstract
Given the demographics of current and ex-smoking populations in North America, lung cancer will be a major problem in the foreseeable future. Early detection and treatment of lung cancer holds great promise for the management of this disease. Unlike cervical cancer, the physical, complete removal/destruction of all dysplastic lesions in the bronchial tree is not possible; however, treatment of the lesions using a chemopreventive agent is. Intermediate biomarkers have been used to screen promising chemopreventive agents for larger population studies. We have examined the natural history of lung cancer development by following a group of subjects at high risk of developing lung cancer using fluorescence endoscopy to identify the areas of abnormality for biopsy. ∼900 biopsies have been collected in this fashion and graded by at least two experienced, expert pathologists. Using an interactive version of the Cyto-Savant (Oncometrics Imaging Corp.), cytometric and tissue architectural data were collected from these biopsies. Using only the data from the normal and invasive cancer biopsies, quantitative morphometric and architectural indices were generated and calculated for all the collected biopsies. These indices were compared with Loss of Heterozygosity (LOH) of ten sites commonly associated with cancer. These results and the application of these quantitative measures to two small chemoprevention studies will be reported.
Original language | English (US) |
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Title of host publication | Proceedings of SPIE - The International Society for Optical Engineering |
Editors | D.L. Farkas, R.C. Leif, B.J. Tromberg |
Pages | 207-211 |
Number of pages | 5 |
Volume | 3260 |
DOIs | |
State | Published - 1998 |
Event | Optical Investigations of Cells In Vitro and In Vivo - San Jose, CA, United States Duration: Jan 25 1998 → Jan 28 1998 |
Other
Other | Optical Investigations of Cells In Vitro and In Vivo |
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Country/Territory | United States |
City | San Jose, CA |
Period | 1/25/98 → 1/28/98 |
Keywords
- Cellular sociology
- Chemoprevention
- LOH
- Quantitative microscopy
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Condensed Matter Physics