Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

Xing Liu; He Xin Shi; Chen Wang

Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

Xing Liu, He Xin Shi, Chen Wang

Research output: Contribution to journal › Review article › peer-review

Abstract

The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-_κB, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.

Original language	English (US)
Pages (from-to)	817-825
Number of pages	9
Journal	Progress in Biochemistry and Biophysics
Volume	37
Issue number	8
State	Published - Aug 2010

Keywords

Antiviral mechanism
Interferon regulatory factor 3
Post-translational modification
Signal transduction
Transcription regulation

ASJC Scopus subject areas

Biophysics
Biochemistry

Cite this

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title = "Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses",

abstract = "The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-κB, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.",

keywords = "Antiviral mechanism, Interferon regulatory factor 3, Post-translational modification, Signal transduction, Transcription regulation",

author = "Xing Liu and Shi, {He Xin} and Chen Wang",

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language = "English (US)",

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journal = "Progress in Biochemistry and Biophysics",

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T1 - Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

AU - Liu, Xing

AU - Shi, He Xin

AU - Wang, Chen

PY - 2010/8

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N2 - The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-κB, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.

AB - The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-κB, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms.

KW - Antiviral mechanism

KW - Interferon regulatory factor 3

KW - Post-translational modification

KW - Signal transduction

KW - Transcription regulation

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M3 - Review article

AN - SCOPUS:78649277272

SN - 1000-3282

VL - 37

SP - 817

EP - 825

JO - Progress in Biochemistry and Biophysics

JF - Progress in Biochemistry and Biophysics

IS - 8

ER -

Interferon regulatory factor 3, a pivotal transcription factor for host antiviral responses

Abstract

Keywords

ASJC Scopus subject areas

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