Interactions Between Toxoplasma Effectors and Host Immune Responses

Barbara A. Butcher; Michael L. Reese; John C. Boothroyd; Eric Y. Denkers

doi:10.1016/B978-0-12-396481-6.00014-3

Interactions Between Toxoplasma Effectors and Host Immune Responses

Barbara A. Butcher, Michael L. Reese, John C. Boothroyd, Eric Y. Denkers

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.

Original language	English (US)
Title of host publication	Toxoplasma Gondii
Subtitle of host publication	The Model Apicomplexan - Perspectives and Methods: Second Edition
Publisher	Elsevier Ltd
Pages	505-519
Number of pages	15
ISBN (Print)	9780123964816
DOIs	https://doi.org/10.1016/B978-0-12-396481-6.00014-3
State	Published - Sep 2013

Keywords

Macrophage
Pseudokinase
ROP kinase
Rhoptry

ASJC Scopus subject areas

General Immunology and Microbiology

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10.1016/B978-0-12-396481-6.00014-3

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title = "Interactions Between Toxoplasma Effectors and Host Immune Responses",

abstract = "As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.",

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AU - Butcher, Barbara A.

AU - Reese, Michael L.

AU - Boothroyd, John C.

AU - Denkers, Eric Y.

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Y1 - 2013/9

N2 - As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.

AB - As an intracellular parasite, Toxoplasma gondii must avoid a variety of host defences including the host immune response. Recent studies have demonstrated that T. gondii extensively remodels its host altering host metabolism and gene expression. These events are mediated by parasite products that are secreted into the host cell during and after invasion. This chapter discusses the identification and mechanism of action of the rhoptry and dense granule proteins that alter host cell signalling and immune response.

KW - Macrophage

KW - Pseudokinase

KW - ROP kinase

KW - Rhoptry

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SP - 505

EP - 519

BT - Toxoplasma Gondii

PB - Elsevier Ltd

ER -

Interactions Between Toxoplasma Effectors and Host Immune Responses

Abstract

Keywords

ASJC Scopus subject areas

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