@article{6308594bf4794016b22f451f5bed2596,
title = "Integrated photodynamic Raman theranostic system for cancer diagnosis, treatment, and post-treatment molecular monitoring",
abstract = "Theranostics, the combination of diagnosis and therapy, has long held promise as a means to achieving personalised precision cancer treatments. However, despite its potential, theranostics has yet to realise significant clinical translation, largely due the complexity and overriding toxicity concerns of existing theranostic nanoparticle strategies. Methods: Here, we present an alternative nanoparticle-free theranostic approach based on simultaneous Raman spectroscopy and photodynamic therapy (PDT) in an integrated clinical platform for cancer theranostics. Results: We detail the compatibility of Raman spectroscopy and PDT for cancer theranostics, whereby Raman spectroscopic diagnosis can be performed on PDT photosensitiser-positive cells and tissues without inadvertent photosensitiser activation/photobleaching or impaired diagnostic capacity. We further demonstrate that our theranostic platform enables in vivo tumour diagnosis, treatment, and post-treatment molecular monitoring in real-time. Conclusion: This system thus achieves effective theranostic performance, providing a promising new avenue towards the clinical realisation of theranostics.",
keywords = "Cancer, Nanoparticle-free, Photodynamic therapy, Raman spectroscopy, Theranostics",
author = "Horgan, {Conor C.} and Bergholt, {Mads S.} and Anika Nagelkerke and Thin, {May Zaw} and Pence, {Isaac J.} and Ulrike Kauscher and Kalber, {Tammy L.} and Stuckey, {Daniel J.} and Stevens, {Molly M.}",
note = "Funding Information: C.C.H. acknowledges funding from the NanoMed Marie Sk{\l}odowska-Curie ITN from the H2020 programme under grant number 676137. M.S.B. acknowledges support from H2020 through the Individual Marie Sk{\l}odowska-Curie Fellowship “IMAGINE” (701713). A.N. and M.M.S. acknowledge support from the GlaxoSmithKline Engineered Medicines Laboratory. M.Z.T. and T.L.K. acknowledge funding from the EPSRC for the award of an Early Career Fellowship EP/L006472/1. I.J.P. acknowledges support from the Whitaker International Program, Institute of International Education, United States of America. U.K. acknowledges support from the Deutsche Forschungsgemeinschaft [KA 4370/1-1]. D.J.S. acknowledges support from a British Heart Foundation Intermediate Basic Science Research Fellowship (FS/15/33/31608), the MRC MR/ R026416/1 and the Wellcome Trust (212937/Z/18/Z). M.M.S. acknowledges a Wellcome Trust Senior Investigator Award (098411/Z/12/Z). The authors acknowledge support from NIHR Imperial Biomedical Research Centre and the Institute of Cancer Research, London, through the joint Cancer Research Centre of Excellence (CRCE). The authors also acknowledge use of microscopy facilities within the Facility for Imaging by Light Microscopy (FILM) at Imperial College London, which is part-supported by funding from the Wellcome Trust (grant 104931/ Z/14/Z). Raw data is available upon reasonable request from rdm-enquiries@imperial.ac.uk. Publisher Copyright: {\textcopyright} The author(s).",
year = "2021",
month = jan,
day = "1",
doi = "10.7150/thno.53031",
language = "English (US)",
volume = "11",
pages = "2006--2019",
journal = "Theranostics",
issn = "1838-7640",
publisher = "Ivyspring International Publisher",
number = "4",
}