TY - JOUR
T1 - Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells implications in thymic aging
AU - Kelley, K. W.
AU - Meier, W. A.
AU - Minshall, Christian T
AU - Schacher, D. H.
AU - Liu, Q.
AU - Vanhoy, R.
AU - Burgess, W.
AU - Dantzer, R.
PY - 1998/5/1
Y1 - 1998/5/1
N2 - A decline in plasma concentrations of both growth hormone and IGF-I occurs during aging of humans and rodents, and this is accompanied by involution of the thymus gland. Exogenous growth hormone induces the synthesis of IGF-I, which acts on bone marrow-derived hematopoietic progenitors of the myeloid and lymphoid lineages to promote their replication and survival. The increase in survival of these cells is caused by the ability of IGF-I to inhibit their apopotic death. In contrast to the multipotential colony-stimulating-factor IL-3, inhibition of apoptosis by IGF-I requires the activation of the critical intracellular effector PI 3-kinase. These data establish that hematopoietic progenitors can use more than one intracellular signaling pathway in order to maintain their survival. The data also extend the original hypothesis48 that IGF-I shares with the colony-stimulating factors the properties of promoting DNA synthesis and inhibiting programmed cell death. Collectively, these data establish that hematopoietic progenitor cells are important targets for IGF-I, and this is likely to be important in understanding thymic aging.
AB - A decline in plasma concentrations of both growth hormone and IGF-I occurs during aging of humans and rodents, and this is accompanied by involution of the thymus gland. Exogenous growth hormone induces the synthesis of IGF-I, which acts on bone marrow-derived hematopoietic progenitors of the myeloid and lymphoid lineages to promote their replication and survival. The increase in survival of these cells is caused by the ability of IGF-I to inhibit their apopotic death. In contrast to the multipotential colony-stimulating-factor IL-3, inhibition of apoptosis by IGF-I requires the activation of the critical intracellular effector PI 3-kinase. These data establish that hematopoietic progenitors can use more than one intracellular signaling pathway in order to maintain their survival. The data also extend the original hypothesis48 that IGF-I shares with the colony-stimulating factors the properties of promoting DNA synthesis and inhibiting programmed cell death. Collectively, these data establish that hematopoietic progenitor cells are important targets for IGF-I, and this is likely to be important in understanding thymic aging.
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U2 - 10.1111/j.1749-6632.1998.tb09590.x
DO - 10.1111/j.1749-6632.1998.tb09590.x
M3 - Article
C2 - 9629278
AN - SCOPUS:0032078403
SN - 0077-8923
VL - 840
SP - 518
EP - 524
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -