Insulin growth factor-I inhibits apoptosis in hematopoietic progenitor cells implications in thymic aging

K. W. Kelley, W. A. Meier, Christian T Minshall, D. H. Schacher, Q. Liu, R. Vanhoy, W. Burgess, R. Dantzer

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


A decline in plasma concentrations of both growth hormone and IGF-I occurs during aging of humans and rodents, and this is accompanied by involution of the thymus gland. Exogenous growth hormone induces the synthesis of IGF-I, which acts on bone marrow-derived hematopoietic progenitors of the myeloid and lymphoid lineages to promote their replication and survival. The increase in survival of these cells is caused by the ability of IGF-I to inhibit their apopotic death. In contrast to the multipotential colony-stimulating-factor IL-3, inhibition of apoptosis by IGF-I requires the activation of the critical intracellular effector PI 3-kinase. These data establish that hematopoietic progenitors can use more than one intracellular signaling pathway in order to maintain their survival. The data also extend the original hypothesis48 that IGF-I shares with the colony-stimulating factors the properties of promoting DNA synthesis and inhibiting programmed cell death. Collectively, these data establish that hematopoietic progenitor cells are important targets for IGF-I, and this is likely to be important in understanding thymic aging.

Original languageEnglish (US)
Pages (from-to)518-524
Number of pages7
JournalAnnals of the New York Academy of Sciences
StatePublished - May 1 1998

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science


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