Insulin detemir: A historical perspective on a modern basal insulin analogue

Luigi Meneghini, Andreas Liebl, Martin J. Abrahamson

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Insulin detemir provides prolonged, reproducible blood glucose reduction through a mechanism unique among basal insulins. It was originally studied clinically in predominantly basal + bolus regimens and found to be associated with a low risk of hypoglycaemia compared to insulin NPH, and reduced weight gain compared to other basal insulins. Insulin detemir has been increasingly studied in basal-only insulin regimens in type 2 diabetes, in which an understanding of how to optimize its use has been built incrementally. Glycaemic control and limitation of weight gain tend to be maximized by once-daily (evening) dosing, earlier initiation and careful titration to appropriate fasting glucose targets.

Original languageEnglish (US)
Pages (from-to)S31-S42
JournalPrimary care diabetes
StatePublished - Apr 2010


  • Basal insulin analogue
  • Hypoglycemia
  • Insulin detemir
  • Weight gain

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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