@article{09a8fc0af5ef4677ba1da306b1a2a877,
title = "Insights into the evolution of longevity from the bowhead whale genome",
abstract = "The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly thelongest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online (http://www.bowhead-whale.org) to facilitate research in this long-lived species.",
author = "Michael Keane and Jeremy Semeiks and Webb, {Andrew E.} and Li, {Yang I.} and V{\'i}ctor Quesada and Thomas Craig and Madsen, {Lone Bruhn} and {van Dam}, Sipko and David Brawand and Marques, {Patr{\'i}cia I.} and Pawel Michalak and Lin Kang and Jong Bhak and Yim, {Hyung Soon} and Grishin, {Nick V.} and Nielsen, {Nynne Hjort} and Heide-J{\o}rgensen, {Mads Peter} and Oziolor, {Elias M.} and Matson, {Cole W.} and Church, {George M.} and Stuart, {Gary W.} and Patton, {John C.} and George, {J. Craig} and Robert Suydam and Knud Larsen and Carlos L{\'o}pez-Ot{\'i}n and O'Connell, {Mary J.} and Bickham, {John W.} and Bo Thomsen and deMagalh{\~a}es, {Jo{\~a}oPedro P.}",
note = "Funding Information: This project was supported by grants from the Life Extension Foundation and the Methuselah Foundation to J.P.M. We thank the Inuit whaling captains of the Alaska Eskimo Whaling Commission and the Barrow Whaling Captains{\textquoteright} Association for allowing us to sample their whales and their willingness to support the transcriptome study. This study was also partly funded by the Augustinus Foundation to K.L. T.C. was supported by a Wellcome Trust grant (WT094386MA) to J.P.M. and M.K. was supported by a studentship from the University of Liverpool{\textquoteright}s Faculty of Health and Life Sciences. J.S. was supported by grants from the NIH (GM094575 to N.V.G.) and the Welch Foundation (I-1505 to N.V.G.). Y.I.L. was supported by a Nuffield Department of Medicine Prize studentship from the University of Oxford. C.L.-O. is an Investigator of the Botin Foundation also supported by grants from Ministerio de Econom{\'i}a y Competitividad-Spain and Instituto de Salud Carlos III (RTICC)-Spain. M.J.O. and A.E.W. are funded by Science Foundation Ireland Research Frontiers Programme Grant (EOB2763) to M.J.O. M.J.O. would also like to acknowledge the Fulbright Commission for the Fulbright Scholar Award 2012-2013. M.J.O. and A.E.W. thank the SFI/HEA Irish Centre for High-End Computing (ICHEC) for processor time and technical support. This work was also supported by the Korea Institute of Ocean Science and Technology (KIOST) in-house program (PE99212). Further thanks to Prof. Chris Ponting and Dr. Andreas Heger for hosting gene orthology predictions from OPTIC, the University of Liverpool High Performance Computing facilities for processor time, Eric de Sousa for help with RNA-seq data analysis, and to Louise Crompton for assistance in compiling and formatting the bibliography. Last, we are grateful to the staff at the Liverpool Centre for Genomic Research for advice during this project. Publisher Copyright: {\textcopyright} 2015 The Authors.",
year = "2015",
month = jan,
day = "6",
doi = "10.1016/j.celrep.2014.12.008",
language = "English (US)",
volume = "10",
pages = "112--122",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",
}