Insights into the evolution of longevity from the bowhead whale genome

Michael Keane, Jeremy Semeiks, Andrew E. Webb, Yang I. Li, Víctor Quesada, Thomas Craig, Lone Bruhn Madsen, Sipko van Dam, David Brawand, Patrícia I. Marques, Pawel Michalak, Lin Kang, Jong Bhak, Hyung Soon Yim, Nick V. Grishin, Nynne Hjort Nielsen, Mads Peter Heide-Jørgensen, Elias M. Oziolor, Cole W. Matson, George M. ChurchGary W. Stuart, John C. Patton, J. Craig George, Robert Suydam, Knud Larsen, Carlos López-Otín, Mary J. O'Connell, John W. Bickham, Bo Thomsen, JoãoPedro P. deMagalhães

Research output: Contribution to journalArticlepeer-review

210 Scopus citations


The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly thelongest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In addition, we identify gene gain and loss involving genes associated with DNA repair, cell-cycle regulation, cancer, and aging. Our results expand our understanding of the evolution of mammalian longevity and suggest possible players involved in adaptive genetic changes conferring cancer resistance. We also found potentially relevant changes in genes related to additional processes, including thermoregulation, sensory perception, dietary adaptations, and immune response. Our data are made available online ( to facilitate research in this long-lived species.

Original languageEnglish (US)
Pages (from-to)112-122
Number of pages11
JournalCell Reports
Issue number1
StatePublished - Jan 6 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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