@article{84892a74470f4a519e3680d6a14040cb,
title = "Insights into retinal development using live imaging in female carriers of choroideremia",
abstract = "Lineage tracing can provide key insights into the development of tissues, such as the retina. Yet it is not possible to manipulate human cells during embryogenesis. The authors observed a distinct phenotype in female carriers of X-linked disorders, in particular, carriers of choroideremia caused by mutations in CHM, encoding Rab escort protein-1. The authors found that X chromosome inactivation provides a method for retinal lineage tracing in human patients. Live imaging of female carriers displays a developmental pattern that is different within the peripheral retina compared with the posterior retina and provides important insights into the development and migration of retinal cells.",
author = "Wert, {Katherine J.} and Benjamin Bakall and Bassuk, {Alexander G.} and Tsang, {Stephen H.} and Mahajan, {Vinit B.}",
note = "Funding Information: Originally submitted February 24, 2018. Revision received February 24, 2018. Accepted for publication June 4, 2018. Drs. Mahajan and Bassuk are supported by NIH grants (R01EY026682, R01EY024665, R01EY025225, R01EY024698, R21AG050437, P30EY026877) and Research to Prevent Blindness (RPB), New York, New York. The Barbara & Donald Jonas Laboratory of Regenerative Medicine and Bernard & Shirlee Brown Glaucoma Laboratory are supported by the National Institute of Health (5P30EY019007, R01EY018213, R01EY024698, R21AG050437), National Cancer Institute Core (5P30CA013696), the RPB Physician-Scientist Award, and unrestricted funds from RPB. Dr. Tsang is a member of the RD-CURE Consortium and is supported by the Tistou and Charlotte Kerstan Foundation, the Schneeweiss Stem Cell Fund, New York State (C029572), the Joel Hoffman Fund, the Professor Gertrude Rothschild Stem Cell Foundation, and the Gebroe Family Foundation. The remaining authors report no relevant financial disclosures. Address correspondence to Vinit B. Mahajan, MD, PhD, Omics Laboratory, Byers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304; email: vinit.mahajan@stanford. edu. doi: 10.3928/23258160-20190503-15 Publisher Copyright: {\textcopyright} 2019 Slack Incorporated. All rights reserved.",
year = "2019",
doi = "10.3928/23258160-20190503-15",
language = "English (US)",
volume = "50",
pages = "E158--E162",
journal = "Ophthalmic Surgery and Lasers",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "5",
}