Abstract
Lineage tracing can provide key insights into the development of tissues, such as the retina. Yet it is not possible to manipulate human cells during embryogenesis. The authors observed a distinct phenotype in female carriers of X-linked disorders, in particular, carriers of choroideremia caused by mutations in CHM, encoding Rab escort protein-1. The authors found that X chromosome inactivation provides a method for retinal lineage tracing in human patients. Live imaging of female carriers displays a developmental pattern that is different within the peripheral retina compared with the posterior retina and provides important insights into the development and migration of retinal cells.
Original language | English (US) |
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Pages (from-to) | E158-E162 |
Journal | Ophthalmic Surgery Lasers and Imaging Retina |
Volume | 50 |
Issue number | 5 |
DOIs | |
State | Published - 2019 |
Externally published | Yes |
ASJC Scopus subject areas
- Surgery
- Ophthalmology