Abstract
Background: Insig proteins are required for feedback regulation of cholesterol synthesis in cultured cells and liver. Insig may play a similar role in intestine. Results: Insig deficiency in enterocytes leads to constitutively elevated cholesterol synthesis in intestine. Conclusion: Intestinal regulation of cholesterol homeostasis requires Insig. Significance: This work provides insight into how enterocytes coordinately balance de novo cholesterol synthesis and absorption.
Original language | English (US) |
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Pages (from-to) | 2148-2156 |
Number of pages | 9 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 4 |
DOIs | |
State | Published - Jan 24 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology