Background: Insig proteins are required for feedback regulation of cholesterol synthesis in cultured cells and liver. Insig may play a similar role in intestine. Results: Insig deficiency in enterocytes leads to constitutively elevated cholesterol synthesis in intestine. Conclusion: Intestinal regulation of cholesterol homeostasis requires Insig. Significance: This work provides insight into how enterocytes coordinately balance de novo cholesterol synthesis and absorption.
|Original language||English (US)|
|Number of pages||9|
|Journal||Journal of Biological Chemistry|
|State||Published - Jan 24 2014|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology