TY - JOUR
T1 - Input to the Lateral Habenula from the Basal Ganglia Is Excitatory, Aversive, and Suppressed by Serotonin
AU - Shabel, Steven J.
AU - Proulx, Christophe D.
AU - Trias, Anthony
AU - Murphy, Ryan T.
AU - Malinow, Roberto
N1 - Funding Information:
We thank Dr. Karl Deisseroth for providing ChR2 cDNA and Dr. Chihye Chung for expert technical assistance. Support provided by NIH (S.J.S. and R.M.) and a postdoctoral award from the Instituts de Recherche en Santé du Canada (C.D.P.). S.J.S., C.D.P., A.T., and R.T.M. performed and analyzed experiments; S.J.S. and C.D.P made the figures; S.J.S., C.D.P., and R.M. designed the study; and S.J.S., C.D.P., and R.M. wrote the manuscript.
PY - 2012/5/10
Y1 - 2012/5/10
N2 - The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the LHb is excitatory, glutamatergic, and suppressed by serotonin. Behaviorally, activation of this pathway is aversive, consistent with its role as an " antireward" signal. Our demonstration of an excitatory projection from the basal ganglia to the LHb explains how LHb-projecting basal ganglia neurons can have similar encoding properties as LHb neurons themselves. Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression.
AB - The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the LHb is excitatory, glutamatergic, and suppressed by serotonin. Behaviorally, activation of this pathway is aversive, consistent with its role as an " antireward" signal. Our demonstration of an excitatory projection from the basal ganglia to the LHb explains how LHb-projecting basal ganglia neurons can have similar encoding properties as LHb neurons themselves. Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression.
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U2 - 10.1016/j.neuron.2012.02.037
DO - 10.1016/j.neuron.2012.02.037
M3 - Article
C2 - 22578499
AN - SCOPUS:84860678825
SN - 0896-6273
VL - 74
SP - 475
EP - 481
JO - Neuron
JF - Neuron
IS - 3
ER -