Initiation of human parturition: V. Progesterone binding substance in fetal membranes

B. E. Schwarz, L. Milewich, J. M. Johnston, J. C. Porter, P. C. MacDonald

Research output: Contribution to journalArticlepeer-review


This study was undertaken as part of an investigation of the potential role of progesterone metabolism within fetal membranes in the initiation of human labor. The results of this study provide evidence that a progesterone binding substance is present in amnion and chorian laeve during the last few days of pregnancy. This substance binds progesterone, cortisol, and 5α-dihydroprogesterone but does not bind 20α-hydroxy-4-pregncn-3-one, R 5020, or dexamethasone. We conclude that this is a previously undescribed progesterone binding substance and propose a possible mechanism by which this substance may be involved in the initiation of human parturition.

Original languageEnglish (US)
Pages (from-to)685-689
Number of pages5
JournalObstetrics and gynecology
Issue number6
StatePublished - Dec 1976

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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