Inhibition of cellular adhesiveness by sulfhydryl blocking agents

F. Grinnell, P. A. Shere

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Rat hepatoma cells rapidly adhered to the polystyrene surfaces of culture bottles. The adhesiveness of the cells was inhibited by sulfhydryl blocking reagents including mercurials, arsenicals, and alkylating agents. Inhibition was prevented, and in some cases reversed, by the addition of dithiothreitol to the adhesive medium. The current model explaining cellular adhesion is discussed in the light of these observations.

Original languageEnglish (US)
Pages (from-to)153-157
Number of pages5
JournalJournal of cellular physiology
Issue number1
StatePublished - Aug 1971

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology


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