Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan; S. Karthigayan; M. Sri Balasubashini; S. Vijayalakshmi; S. T. Somasundaram; T. Balasubramanian

doi:10.3923/ijcr.2007.186.190

Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

R. Karthikeyan, S. Karthigayan, M. Sri Balasubashini, S. Vijayalakshmi, S. T. Somasundaram, T. Balasubramanian

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL^-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

Original language	English (US)
Pages (from-to)	186-190
Number of pages	5
Journal	International Journal of Cancer Research
Volume	3
Issue number	4
DOIs	https://doi.org/10.3923/ijcr.2007.186.190
State	Published - 2007

Keywords

Antitumor
Cell line
Ehrlich's ascites carcinoma
Hydrophis spiralis
Sea snake venom

ASJC Scopus subject areas

Oncology
Cancer Research

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10.3923/ijcr.2007.186.190

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title = "Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom",

abstract = "The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.",

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author = "R. Karthikeyan and S. Karthigayan and {Sri Balasubashini}, M. and S. Vijayalakshmi and Somasundaram, {S. T.} and T. Balasubramanian",

year = "2007",

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AU - Karthikeyan, R.

AU - Karthigayan, S.

AU - Sri Balasubashini, M.

AU - Vijayalakshmi, S.

AU - Somasundaram, S. T.

AU - Balasubramanian, T.

PY - 2007

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AB - The anti-tumor activity of the sea snake venom (Hydrophis spiralis) was evaluated against Ehrlich's Ascites Carcinoma (EAC) in Swiss albino mice and HeLa and Hep2 tumor cell cultures. Among the different dose tested 4.18 μg mL-1 at 24 h was found to effectively inhibit cancer cell proliferation. The same dose on EAC-bearing mice by i.p. injection significantly reduced the tumor growth and was demonstrated by increased life span of the mice by 182.81%.

KW - Antitumor

KW - Cell line

KW - Ehrlich's ascites carcinoma

KW - Hydrophis spiralis

KW - Sea snake venom

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Inhibition of cancer cell proliferation in vitro and tumor growth in vivo by Hydrophis spiralis sea snake venom

Abstract

Keywords

ASJC Scopus subject areas

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