Inhibition of alanine stimulated glucagon secretion by secretin in the dog

F. Santeusanio, G. R. Faloona, Roger H Unger

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


In a group of 4 dogs the infusion of 10 U of secretin per min for a 20 min period during alanine induced hyperglucagonemia (1 mmole of alanine per kg over 60 min) was associated with a prompt and uniform suppression of both peripheral and pancreatico duodenal vein glucagon concentrations to or below basal levels, and a rapid return to stimulated levels when secretin was terminated. The secretin induced fall in glucagon was associated with a decline in plasma glucose which averaged 15 mg/100 ml, and which could not be explained by increased insulin secretion. 10 U of secretin per min infused simultaneously with approximately equimolar amounts of pancreozymin (7.5 Ivy units per min) failed to reduce the pancreozymin stimulated increase in glucagon, however.

Original languageEnglish (US)
Pages (from-to)425-427
Number of pages3
JournalHormone and Metabolic Research
Issue number6
StatePublished - 1973

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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