Inhaled albuterol increases estimated ventilatory capacity in nonasthmatic children without and with obesity

Daniel P. Wilhite, Dharini M. Bhammar, Bryce N. Balmain, Tanya Martinez-Fernandez, Tony G. Babb

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Forced mid-expiratory flow (i.e., isoFEF25−75) may increase with a short-acting β2-agonist in nonasthmatic children without bronchodilator responsiveness. This could also increase estimated ventilatory capacity along mid-expiration (V̇Ecap25−75), especially in vulnerable children with obesity who exhibit altered breathing mechanics. We estimated V̇Ecap25−75 pre- and post-albuterol treatment in 8−12yo children without (n = 28) and with (n = 46) obesity. A two-way ANOVA was performed to determine effects of an inhaled bronchodilator (pre-post) and obesity (group) on isoFEF25−75 and V̇Ecap25−75. There was no group by bronchodilator interaction or main group effect on outcome variables. However, a significant main effect of the bronchodilator was detected in spirometry parameters, including a substantial increase in isoFEF25−75 (17.1 ± 18.0 %) and only a slight (non-clinical) but significant increase in FEV1 (2.4 ± 4.3 %). V̇Ecap25−75 significantly increased with albuterol (+11.7 ± 10.6 L/min; +15.8 ± 13.9 %). These findings imply potentially important increases in ventilatory reserve with a bronchodilator in nonasthmatic children without and with obesity, which could potentially influence respiratory function at rest and during exercise.

Original languageEnglish (US)
Article number103597
JournalRespiratory Physiology and Neurobiology
StatePublished - Mar 2021


  • Bronchodilator
  • FEF
  • FEV
  • Forced expiratory flow
  • Responsiveness
  • Spirometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine


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