Influence of suspension hypokinesia on rat soleus muscle

G. H. Templeton, M. Padalino, J. Manton, M. Glasberg, C. J. Silver, P. Silver, G. DeMartino, T. Leconey, G. Klug, H. Hagler

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91 Scopus citations


Hindlimb hypokinesia was induced in rats by the Morey method to characterize the response of the soleus muscle. Rats suspended for 1-4 wk exhibited continuous and significant declines in soleus mass, function, and contractile duration. Soleus speeding was in part explained by an alteration in fiber type. The normal incidence of 70-90% type I fibers in the soleus muscle was reduced after 4 wk of suspension to 50% or less in 9 of 11 rats. A significant decline in type I myosin isozyme content occurred without a change in that of type II. Other observed histochemical changes were characteristic of denervation. Consistent with soleus atrophy, there was a significant increase in lysosomal (aci) protease activity. One week of recovery after a 2-wk suspension was characterized by a return to values not significantly different from control for muscle wet weights, peak contraction force, one-half relaxation time, and type I myosin. Persistent differences from control were observed in maximal rate of tension development, contraction time, and denervation-like changes.

Original languageEnglish (US)
Pages (from-to)278-286
Number of pages9
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Issue number2
StatePublished - 1984

ASJC Scopus subject areas

  • Physiology
  • Endocrinology


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