TY - JOUR
T1 - Influence of plasma triglycerides on lipoprotein patterns in normal subjects and in patients with coronary artery disease
AU - Richards, E. Glen
AU - Grundy, Scott M
AU - Cooper, Kenneth
N1 - Funding Information:
From the Veterans Administration Medical Center, Dallas, Texas; the Departments of Internal Medicine and Biochemistry and the Center for Human Nutrition, the University of Texas Southwestern Medical Center at Dallas; and the Institute for Aerobic Research, Dallas. This study was supported by the Veterans Administration; grant HL-29252 from the National Institutes of Health, Bethesda, Maryland; the Southwestern Medical Foundation, Dallas; and the Moss Heart Foundation, Dallas. Manuscript received December 5, 1988; revised manuscript received and accepted February 21, 1989.
PY - 1989/5/15
Y1 - 1989/5/15
N2 - This study examined the correlation of plasma triglyceride levels with concentrations of intermediate, low and high density lipoproteins (IDL, LDL, and HDL, respectively) and to particle sizes of LDL in 93 normal men and 106 men with coronary artery disease. Plasma triglyceride concentrations were in the normal range for all persons in both groups. Analysis of lipoproteins of density <1.063 g/ml was carried out by analytical ultracentrifugation. The analytical pattern gave the peak Sf for LDL as well as an indication of heterogeneity of particle sizes in the density range of LDL. In both normal subjects and patients with coronary artery disease, a positive correlation was found between peak Sf for LDL and concentrations of plasma triglycerides. Plasma triglyceride levels also were correlated positively with concentrations of Sf 20 to 60 lipoproteins and total IDL mass, and inversely with HDL cholesterol levels. Furthermore, the value for peak Sf for LDL correlated inversely with the IDL mass concentration and IDL LDL mass ratio, and positively with the HDL cholesterol levels. The results indicate that the lipoprotein pattern, including lipoprotein concentrations and particle sizes, is sensitive to concentrations of plasma triglycerides even when the latter are within the normal range.
AB - This study examined the correlation of plasma triglyceride levels with concentrations of intermediate, low and high density lipoproteins (IDL, LDL, and HDL, respectively) and to particle sizes of LDL in 93 normal men and 106 men with coronary artery disease. Plasma triglyceride concentrations were in the normal range for all persons in both groups. Analysis of lipoproteins of density <1.063 g/ml was carried out by analytical ultracentrifugation. The analytical pattern gave the peak Sf for LDL as well as an indication of heterogeneity of particle sizes in the density range of LDL. In both normal subjects and patients with coronary artery disease, a positive correlation was found between peak Sf for LDL and concentrations of plasma triglycerides. Plasma triglyceride levels also were correlated positively with concentrations of Sf 20 to 60 lipoproteins and total IDL mass, and inversely with HDL cholesterol levels. Furthermore, the value for peak Sf for LDL correlated inversely with the IDL mass concentration and IDL LDL mass ratio, and positively with the HDL cholesterol levels. The results indicate that the lipoprotein pattern, including lipoprotein concentrations and particle sizes, is sensitive to concentrations of plasma triglycerides even when the latter are within the normal range.
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U2 - 10.1016/0002-9149(89)90181-1
DO - 10.1016/0002-9149(89)90181-1
M3 - Article
C2 - 2711991
AN - SCOPUS:0024554479
SN - 0002-9149
VL - 63
SP - 1214
EP - 1220
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 17
ER -